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Synfacts 2007(2): 0195-0195  
DOI: 10.1055/s-2006-955805
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

A Versatile Triol Ligand for Cu-Catalyzed Reactions of Aryl Iodides

Contributor(s): Paul Knochel, Andrei Gavryushin
Y.-J. Chen*, H.-H. Chen
National Chung-Hsing University, Taiwan
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Publication History

Publication Date:
23 January 2007 (online)

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Significance

Reactions of aryl halides with hetero­atomic nucleophiles have become an important method for the preparation of numerous intermediates in organic synthesis. This publication describes a new simple and versatile protocol for the copper-catalyzed arylation of amides, phenols and thiols with aryl iodides in the presence of a simple triol ligand. The reaction conditions are mild and the reaction may tolerate various functional groups.