Synfacts 2007(2): 0198-0198  
DOI: 10.1055/s-2006-955795
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

General Preparation of Amines by Oxidative Coupling of Amidocuprates

Contributor(s): Paul Knochel, Andrei Gavryushin
V. del Amo, S. R. Dubbaka, A. Krasovskiy, P. Knochel*
Ludwig-Maximilians-Universität München, Germany
Further Information

Publication History

Publication Date:
23 January 2007 (online)

Significance

Substituted anilines and heterocyclic amines are important intermediates and target molecules in organic synthesis. The herein reported method allows the preparation of a broad range of mono-, di- and triaryl and heteroaryl­amines, including those bearing a halide group or very bulky substituents, which are difficult to prepare by common Pd-catalyzed amination techniques. Primary, secondary and tertiary amines are readily available by this protocol with excellent functional group compatibility.