Planta Med 2006; 72(15): 1438-1440
DOI: 10.1055/s-2006-951729
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Antiplasmodial Activity of Compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar Rain Forest

Shugeng Cao1 , Lalasoa Ranarivelo2 , Michel Ratsimbason2 , Sennen Randrianasolo2 , Fidy Ratovoson3 , Mamisoa Andrianjafy3 , David G. I. Kingston1
  • 1Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA
  • 2Centre National d’Application des Recherches Pharmaceutiques, Antananarivo, Madagascar
  • 3Missouri Botanical Garden, Antananarivo, Madagascar
Biodiversity Conservation and Drug Discovery in Madagascar, Part 22. For Part 21, see ref. 1
Weitere Informationen

Publikationsverlauf

Received: April 20, 2006

Accepted: September 29, 2006

Publikationsdatum:
07. November 2006 (online)

Preview

Abstract

Bioassay-directed separation of the butanol-soluble portion of an extract of Sloanea rhodantha (Baker) Capuron var. rhodantha (Elaeocarpaceae) active against the drug-sensitive HB3 strain of Plasmodium falciparum led to the isolation of seven phenolic compounds, gallic acid (1), 3,5-di-O-galloylquinic acid (2), 1,6-di-O-galloyl glucopyranoside (3), 3,4,5-tri-O-galloylquinic acid (4), 1-O-eudesmoylquinic acid (5), 1,2,3,6-tetra-O-galloyl glucopyranoside (6), and 3,4,5-trimethoxyphenyl-(6′-O-galloyl)-O-b-D-glucopyranoside (7). The structure of the new compound 5 was established on the basis of interpretation of its 1D and 2D NMR spectroscopic data. Compounds 2, 3, 4, 6, and 7 showed weak inhibitory activity against the drug-sensitive HB3 and the drug-resistant FCM29 strains of P. falciparum, with IC50 values ranging from 8.0 - 43.0 and 16.1 - 93.0 μg/mL, respectively.

References

Prof. Dr. David G. I. Kingston

Department of Chemistry

M/C 0212

Virginia Polytechnic Institute and State University

Blacksburg

Virginia 24061-0212

USA

Telefon: +1-540-231-6570

Fax: +1-540-231-3255

eMail: dkingston@vt.edu