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Semin Neurol 2006; 26(5): 515-522
DOI: 10.1055/s-2006-951624
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Genetic Disorders Producing Compressive Radiculopathy

Joseph M. Corey1
  • 1Department of Neurology, University of Michigan Medical School, Ann Arbor, Michigan
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Publication History

Publication Date:
17 October 2006 (online)

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ABSTRACT

Back pain is a frequent complaint seen in neurological practice. In evaluating back pain, neurologists are asked to evaluate patients for radiculopathy, determine whether they may benefit from surgery, and help guide management. Although disc herniation is the most common etiology of compressive radiculopathy, there are many other causes, including genetic disorders. This article is a discussion of genetic disorders that cause or contribute to radiculopathies. These genetic disorders include neurofibromatosis, Paget's disease of bone, and ankylosing spondylitis. Numerous genetic disorders can also lead to deformities of the spine, including spinal muscular atrophy, Friedreich's ataxia, Charcot-Marie-Tooth disease, familial dysautonomia, idiopathic torsional dystonia, Marfan's syndrome, and Ehlers-Danlos syndrome. However, the extent of radiculopathy caused by spine deformities is essentially absent from the literature. Finally, recent investigation into the heritability of disc degeneration and lumbar disc herniation suggests a significant genetic component in the etiology of lumbar disc disease.

KEYWORDS

Spine - disc degeneration - neurofibromatosis - heredity - collagen disorders - spinal deformity

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Joseph M CoreyM.D. Ph.D. 

Assistant Professor, Department of Neurology, University of Michigan Medical School

5013 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48103-2200

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