Pharmacopsychiatry 2006; 39(6): 236-237
DOI: 10.1055/s-2006-950393
Letter

© Georg Thieme Verlag KG Stuttgart · New York

Cotrimoxazole-induced Psychosis: A Case Report and Review of Literature

S. Weis 1 , D. Karagülle 1 , J. Kornhuber 1 , K. Bayerlein 1
  • 1Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany
Further Information

Publication History

Received 6. 3. 2006 Revised 3. 7. 2006

Accepted 7. 7. 2006

Publication Date:
23 November 2006 (online)

We present a case of acute psychosis in a 46-year-old woman who had been treated orally with cotrimoxazole because of a severe infection of the urinary tract. She had started to develop psychotic symptoms with bizarre behavior two days before admission. Following discontinuation of antibiotic therapy, including cessation of treatment with cotrimoxazole and the induction of antipsychotic treatment, her mental state resolved to a stable premorbid level within 36 hours.

References

  • 1 Gregor JC, Zilli CA, Gotlib IH. Acute psychosis associated with oral trimethoprim-sulfamethoxazole therapy.  Can J Psychiatry. 1993;  38 56-58
  • 2 Howe RA, Spencer RC. Cotrimoxazole. Rationale for re-examining its indications for use.  Drug Saf. 1996;  14 213-218
  • 3 McCue JD, Zandt JR. Acute psychoses associated with the use of ciprofloxacin and trimethoprim-sulfamethoxazole.  Am J Med. 1991;  90 528-529
  • 4 Mermel LA, Doro JM, Kabadi UM. Acute psychosis in a patient receiving trimethoprim-sulfamethoxazole intravenously.  J Clin Psychiatry. 1986;  47 269-270
  • 5 Saidinejad M, Ewald MB, Shannon MW. Transient psychosis in an immune-competent patient after oral trimethoprim-sulfamethoxazole administration.  Pediatrics. 2005;  115 e739-e741
  • 6 Sternbach H, State R. Antibiotics: neuropsychiatric effects and psychotropic interactions.  Harv Rev Psychiatry. 1997;  5 214-226

Correspondence

Stefanie Weis

Klinik mit Poliklinik für Psychiatrie und Psychotherapie

Universitätsklinikum Erlangen

Schwabachanlage 6

D-91054 Erlagen

Phone: +49/91/31 85 34 166

Fax: +49/91/31 85 34 862

Email: stefanie.weis@psych.imed.uni-erlangen.de

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