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Synfacts 2006(11): 1090-1090  
DOI: 10.1055/s-2006-949390
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Mucocin

Contributor(s): Philip Kocienski, John Cooksey
M. T. Crimmins*, Y. Zhang, F. A. Diaz
University of North Carolina at Chapel Hill, USA
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Publication History

Publication Date:
24 October 2006 (online)

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Significance

(-)-Mucocin (isolated from the leaves of Rollinia mucosa) is an antimitotic annonaceous acetogenin polyether. The focal points of the Crimmins group’s total synthesis are the use of glycolate aldol and metathesis reactions.