Semin Hear 2006; 27(3): 193-204
DOI: 10.1055/s-2006-947286
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Future Trends and Potential for Treatment of Sensorineural Hearing Loss

Zippora Brownstein1 , Karen B. Avraham1
  • 1Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
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Publication History

Publication Date:
17 July 2006 (online)

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ABSTRACT

Damage and loss of hair cells in the inner ear is the most frequent cause of hearing loss (HL), since mammalian hair cells are not replenished once lost. To date, the treatment of HL consists of hearing aids or cochlear implants, but both options restore hearing with limited success. Gene therapy is an attractive option as a means for treating sensorineural hearing impairment, although at present it is investigational. The finding that hair cells can regenerate in nonmammalian vertebrates has triggered many studies, with the hope of simulating a similar process in humans. Current research that focuses on the auditory pathways, the genes involved in HL, efficient ways to transfer therapeutic agents into the inner ear, and optimization of gene manipulation, gene therapy, and stem cell treatment raises hope for restoring hearing and curing deafness.

REFERENCES

 Prof.
Karen B AvrahamPh.D. 

Department of Human Molecular Genetics and Biochemistry

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Email: karena@post.tau.ac.il