Planta Med 2006; 72(13): 1231-1234
DOI: 10.1055/s-2006-947189
Letter
© Georg Thieme Verlag KG tuttgart · New York

Diterpenes from ”Pini Resina” and their Preferential Cytotoxic Activity under Nutrient-Deprived Condition

Syed Faisal Haider Zaidi1 , Suresh Awale1 , Surya Kant Kalauni1 , Yasuhiro Tezuka1 , Hiroyasu Esumi2 , Shigetoshi Kadota1
  • 1Institute of Natural Medicine, University of Toyama, Toyama, Japan
  • 2Investigative Treatment Division, National Cancer Research Institute East, Chiba, Japan
Further Information

Publication History

Received: March 12, 2006

Accepted: June 1, 2006

Publication Date:
10 August 2006 (online)

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Abstract

In the course of our search for anticancer agents based on a novel anti-austerity strategy, we found that the 70 % EtOH extract of ”Pini Resina” showed 100 % preferential cytotoxicity at the concentration of 50 μg/mL. Further bioassay-guided fractionation and purification led to the isolation of 15 compounds including one new compound 7-oxo-13α-hydroxyabiet-8(14)-en-18-oic acid (1). Their structures were elucidated on the basis of spectroscopic analysis. Among the isolated compounds, methyl abieta-8,11,13-trien-18-oate (7) showed the most potent preferential cytotoxicity at 10 μg/mL under nutrient-deprived condition.

References

Dr. Prof. Shigetoshi Kadota

Institute of Natural Medicine

University of Toyama

2630 Sugitani

Toyama 930-0194

Japan

Phone: +81-76-434-7625

Fax: +81-76-434-5059

Email: kadota@ms.toyama-mpu.ac.jp