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Synfacts 2006(8): 0855-0855  
DOI: 10.1055/s-2006-941988
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

CuFAP Catalyzed Cross Coupling of Bromo- and Iodoarenes with Heterocycles

Contributor(s): Yasuhiro Uozumi, Toshimasa Suzuka
M. L. Kantam*, G. T. Venkanna, CH. Sridhar, K. B. S. Kumar
Indian Institute of Chemical Technology, Hyderabad, India
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Publication History

Publication Date:
21 July 2006 (online)

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Significance

Ligand-free copper fluorapatite (CuFAP) was found to work as a highly efficient and recyclable catalyst for the cross-coupling of bromo- and iodoarenes with NH containing he­terocycles. Thus, the new heterogeneous copper catalyst supported on fluorapatite (copper loadings of 1.25 mmol/g) was prepared from calcium fluorapatite [derived from Ca(NO3)2, (NH4)2HPO4, and Ca(NO3)2×4H2O] and a water-containing appropriate amount of Cu(OAc)2. The CuFAP catalyst showed high activity in the cross-coupling reaction of bromo- and iodoarenes with NH containing heterocycles (15 examples, 85-98% yields).