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Synfacts 2006(8): 0820-0820  
DOI: 10.1055/s-2006-941945
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Ir-Catalyzed Asymmetric Transfer Hydrogenation of Ketones in Water

Contributor(s): Mark Lautens, Yann Béthuel
X. Li, J. Blacker, I. Houson, X. Wu, J. Xiao*
University of Liverpool and NPIL Pharma, Huddersfield, UK
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Publikationsverlauf

Publikationsdatum:
21. Juli 2006 (online)

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Significance

The first application of a camphorsulfonyl ethylene diamine based ligand in an asymmetric transfer hydrogenation is described. Additionally, the catalyst system is used in an environmentally friendly solvent (neat water) at a low catalyst loading (0.1%) and allows for highly enantioselective reduction of ketones with various electronic properties.