RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2006(7): 0676-0676
DOI: 10.1055/s-2006-941814
DOI: 10.1055/s-2006-941814
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Dynamic Kinetic Resolution of Racemic Ethyl 2-Fluoroacetoacetate
K. Szõri, G. Szöllõsi*, M. Bartók
University of Szeged, Hungary
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Juni 2006 (online)
Significance
Dynamic kinetic resolution is a very useful method to access enantioenriched products. The authors use a cinchona-modified platinum catalyst that is able to racemize the starting material as well as preferentially hydrogenate the S-configured substrate, allowing for successful dynamic kinetic resolution. Many chiral cinchona compounds as well as a variety of solvents were tested. The hydrogen pressure effected the stereoselectivity with 0.1 MPa being optimal.