Synfacts 2006(6): 0545-0545  
DOI: 10.1055/s-2006-934488
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Lamellarin L

Contributor(s): Philip Kocienski, Fiona Black
N. Fujikawa, T. Ohta, T. Yamaguchi, T. Fukada, F. Ishibashi, M. Iwao*
Nagasaki University, Japan
Further Information

Publication History

Publication Date:
19 May 2006 (online)

Preview

Significance

Lamellarins D, L, and N are marine natural products with varying degrees of cyto­toxic activity. A general approach to the unusual 14-phenyl-6H-[1]benzopyrano[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one scaffold is reported using a Hinsberg-type pyrrole synthesis and palladium-catalyzed coupling reactions.