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Synfacts 2006(4): 0379-0379  
DOI: 10.1055/s-2006-932116
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Direct Cyclopropanation of 1-Alkynylphosphonates

Contributor(s): Paul Knochel, Andrei Gavryushin
A. A. Aziz Quntar, M. Srebnik*
Hebrew University in Jerusalem, Israel
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Publikationsverlauf

Publikationsdatum:
24. März 2006 (online)

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Significance

This method is a new application of the known Zr-catalyzed cyclopropanation of alkynes with ethylmagnesium bromide. Substituted cyclopropyl-phosphonates possess a broad range of biological activity and therefore are interesting synthetic targets. Besides, this reaction is a useful step toward the development of a general method for the metal-catalyzed transformation of alkynes into cyclopropanes, based on organometallic chemistry.