A New Cytotoxic Amide from the Stem Wood of Hibiscus tiliaceus

Abstract

A new coumarin, hibiscusin, and a new amide, hibiscusamide, together with eleven known compounds including vanillic acid, p-hydroxybenzoic acid, syringic acid, p-hydroxybenzaldehyde, scopoletin, N-trans-feruloyltyramine, N-cis-feruloyltyramine, a mixture of β-sitosterol and stigmasterol, a mixture of β-sitostenone and stigmasta-4,22-dien-3-one were isolated from the stem wood of Hibiscus tiliaceus. The structures of these new compounds were determined through spectral analyses. Among the isolates, three compounds exhibited cytotoxicity (IC₅₀ values < 4 μg/mL) against P-388 and/or HT-29 cell lines in vitro.

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