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DOI: 10.1055/s-2006-931603
Nobilisides A - C, Three New Triterpene Glycosides from the Sea Cucumber Holothuria nobilis
Publication History
Received: February 14, 2006
Accepted: March 28, 2006
Publication Date:
29 May 2006 (online)
Abstract
Three new triterpene glycosides, named nobilisides A (1), B (2) and C (3), were isolated from the sea cucumber Holothuria nobilis Selenka. Their structures were deduced by extensive spectral analysis and chemical evidence. Compounds 1 and 3 are non-sulfated monoglycosides while 2 is a sulfated diglycoside. The presence of two conjugated double bonds [22E,24-diene and 7,9(11)-diene] in the aglycone of 1 is a rare structural feature among sea cucumber glycosides, while 2 and 3 possess the same 22,25-epoxy moiety as their side chains. All three glycosides exhibited significant cytotoxicity against human tumor cell lines.
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Prof. Yang-Hua Yi
Research Center for Marine Drugs
College of Pharmacy
Second Military Medical University
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