Planta Med 2006; 72(10): 932-935
DOI: 10.1055/s-2006-931603
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Nobilisides A - C, Three New Triterpene Glycosides from the Sea Cucumber Holothuria nobilis

Jun Wu1 , Yang-Hua Yi1 , Hai-Feng Tang2 , Hou-Ming Wu3 , Zhen-Rong Zou1 , Hou-Wen Lin4
  • 1Research Center for Marine Drugs, College of Pharmacy, Second Military Medical University, Shanghai, P. R. China
  • 2Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, P. R. China
  • 3State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai, P. R. China
  • 4Department of Pharmacy, Changzheng Hospital, Shanghai, P. R. China
Further Information

Publication History

Received: February 14, 2006

Accepted: March 28, 2006

Publication Date:
29 May 2006 (online)

Abstract

Three new triterpene glycosides, named nobilisides A (1), B (2) and C (3), were isolated from the sea cucumber Holothuria nobilis Selenka. Their structures were deduced by extensive spectral analysis and chemical evidence. Compounds 1 and 3 are non-sulfated monoglycosides while 2 is a sulfated diglycoside. The presence of two conjugated double bonds [22E,24-diene and 7,9(11)-diene] in the aglycone of 1 is a rare structural feature among sea cucumber glycosides, while 2 and 3 possess the same 22,25-epoxy moiety as their side chains. All three glycosides exhibited significant cytotoxicity against human tumor cell lines.

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Prof. Yang-Hua Yi

Research Center for Marine Drugs

College of Pharmacy

Second Military Medical University

325 GuoHe Road

Shanghai 200433

People’s Republic of China

Phone: +86-21-6538-4988

Fax: +86-21-6548-3662

Email: wu919067@126.com

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