Planta Med 2006; 72(7): 590-595
DOI: 10.1055/s-2006-931565
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Lignans from Saussurea conica and their NO Production Suppressing Activity

Cheng-Qi Fan1 , Xing-Zu Zhu1 , Zha-Jun Zhan1 , Xin-Quan Ji1 , Hui Li2 , Jian-Min Yue1
  • 1State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China
  • 2Tibet Plateau Institute of Biology, Lasa, P. R. China
Further Information

Publication History

Received: July 28, 2005

Accepted: January 10, 2006

Publication Date:
24 April 2006 (online)

Abstract

Three new lignan derivatives, conicaols A and B and conicaoside, together with seven known compounds were identified from Saussurea conica. Their structures were elucidated by spectral methods including 1D and 2D NMR techniques. Six 2,3-dibenzylbutyrolactone-type lignans were biologically evaluated, and two of them, arctigenin and matairesinol, showed potent activity to suppress NO production in vitro in LPS-activated macrophages of SD rat.

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Prof. Jian-Min Yue

State Key Laboratory of Drug Research

Institute of Materia Medica

Shanghai Institute for Biological Sciences

Chinese Academy of Sciences

555 Zu Chong Zhi Road

Zhangjiang Hi-Tech Park

Shanghai 201203

People’s Republic of China

Phone: +86-21-5080-6718

Fax: +86-21-5080-6718

Email: jmyue@mail.shcnc.ac.cn