Download PDF
TumorDiagnostik & Therapie 2006; 27(6): 266-272
DOI: 10.1055/s-2006-927318
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Infektiöse Komplikationen als Folge der Behandlung mit Nukleosidanaloga und monoklonalen Antikörpern

Infectious complications related to nucleoside analogs and
monoclonal antibodiesG. Maschmeyer1 , A. Haas1
  • 1Medizinische Klinik, Abt. Hämatologie und Onkologie, Klinikum Ernst von Bergmann, Potsdam
Further Information

Publication History

eingereicht: 15.5.2006

angenommen: 24.8.2006

Publication Date:
28 December 2006 (online)

Also available at
   Permissions and Reprints
Preview

Schlüsselwörter

Infektionen - Fludarabin - Cladribin - Rituximab - Alemtuzumab - Infliximab - Etanercept - Adalimumab - Basiliximab

Keywords

Infections - Fludarabine - Cladribine - Rituximab - Alemtuzumab - Infliximab - Etanercept - Adalimumab - Basiliximab

Literatur

  • 1 Anaissie E J, Kontoyiannis D P, O’Brien S, Kantarjian H, Robertson L, Lerner S, Keating M J. Infections in patients with chronic lymphocytic leukemia treated with fludarabine.  Ann Intern Med. 1998;  129 559-566
    Search in Google Scholar
  • 2 Byrd J C, Peterson B, Piro L, Saven A, Vardiman J W, Larson R A, Schiffer C. A phase II study of cladribine treatment for fludarabine refractory B cell chronic lymphocytic leukemia: results from CALGB Study 9211.  Leukemia. 2003;  17 323-327
    Search in Google Scholar
  • 3 Cheson B D. Infectious and immunosuppressive complications of purine analog therapy.  J Clin Oncol. 1995;  13 2431-2448
    Search in Google Scholar
  • 4 Coiffier B, Lepage E, Brière J, Herbrecht R, Tilly H, Bouabdallah R, Morel P, Neste E van den, Salles G, Gaulard P, Reyes F, Gisselbrecht C. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma.  N Engl J Med. 2002;  346 235-242
    Search in Google Scholar
  • 5 Couriel D, Saliba R, Hicks K, Ippoliti C, Lima M de, Hosing C, Khouri I, Andersson B, Gajewski J, Donato M, Anderlini P, Kontoyiannis D P, Cohen A, Martin T, Giralt S, Champlin R. Tumor necrosis factor-alpha blockade for the treatment of acute GVHD.  Blood. 2004;  104 649-654
    Search in Google Scholar
  • 6 Dinarello C A. Differences between anti-tumor necrosis factor-alpha monoclonal antibodies and soluble TNF receptors in host defense impairment.  J Rheumatol Suppl. 2005;  74 40-47
    Search in Google Scholar
  • 7 Edwards J C, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close D R, Stevens R M, Shaw T. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis.  N Engl J Med. 2004;  350 2572-2581
    Search in Google Scholar
  • 8 Emery P, Fleischmann R, Filipowicz-Sosnowska A, Schechtman J, Szczepanski L, Kavanaugh A, Racewicz A J, Vollenhoven R F, Li N F, Agarwal S van, Hessey E W, Shaw T M. The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: Results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial.  Arthritis Rheum. 2006;  54 1390-1400
    Search in Google Scholar
  • 9 Eichhorst B F, Busch R, Hopfinger G, Pasold R, Hensel M, Steinbrecher C, Siehl S, Jäger U, Bergmann M, Stilgenbauer S, Schweighofer C, Wendtner C M, Döhner H, Brittinger G, Emmerich B, Hallek M. German CLL Study Group . Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia.  Blood. 2006;  107 885-891
    Search in Google Scholar
  • 10 Fortun J, Martin-Davila P, Barcena R, Lumbreras C, Navasa M, Cisneros J, Pahissa A, Rufi G, Munoz P, Montejo M, Asensio A, Pena F, Torre J de la. Influence of different immunosuppressive regimens on infection in liver transplantation.  45th Interscience Conference on Antimicrobial Agents and Chemotherapy 2005, American Society for Microbiology. 2005;  Abstract #K-1809
    Search in Google Scholar
  • 11 Ghielmini M, Schmitz S F, Cogliatti S B, Pichert G, Hummerjohann J, Waltzer U, Fey M F, Betticher D C, Martinelli G, Peccatori F, Hess U, Zucca E, Stupp R, Kovacsovics T, Helg C, Lohri A, Bargetzi M, Vorobiof D, Cerny T. Prolonged treatment with rituximab in patients with follicular lymphoma significantly increases event-free survival and response duration compared with the standard weekly × 4 schedule.  Blood. 2004;  103 4416-4423
    Search in Google Scholar
  • 12 Goldberg S L, Pecora A L, Alter R S, Kroll M S, Rowley S D, Waintraub S E, Imrit K, Preti R A. Unusual viral infections (progressive multifocal leukoencephalopathy and cytomegalovirus disease) after high-dose chemotherapy with autologous blood stem cell rescue and peritransplantation rituximab.  Blood. 2002;  99 1486-1488
    Search in Google Scholar
  • 13 Gruttadauria S, Vasta F, Mandala L, Cintorino D, Piazza T, Spada M, Verzaro R, Gridelli B. Basiliximab in a triple-drug regimen with tacrolimus and steroids in liver transplantation.  Transplant Proc. 2005;  37 2611-2613
    Search in Google Scholar
  • 14 Hiddemann W, Kneba M, Dreyling M, Schmitz N, Lengfelder E, Schmits R, Reiser M, Metzner B, Harder H, Hegewisch-Becker S, Fischer T, Kropff M, Reis H E, Freund M, Wörmann B, Fuchs R, Planker M, Schimke J, Eimermacher H, Trümper L, Aldaoud A, Parwaresch R, Unterhalt M. Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group.  Blood. 2005;  106 3725-3732
    Search in Google Scholar
  • 15 Kahan B D, Rajagopalan P R, Hall M. United States Simulect Renal Study Group . Reduction of the occurrence of acute cellular rejection among renal allograft recipients treated with basiliximab, a chimeric anti-interleukin-2-receptor monoclonal antibody.  Transplantation. 1999;  67 276-284
    Search in Google Scholar
  • 16 Keane J, Gershon S, Wise R P, Mirabile-Levens E, Kasznica J, Schwieterman W D, Siegel J N, Braun M M. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.  N Engl J Med. 2001;  345 1098-1104
    Search in Google Scholar
  • 17 Keating M J, Flinn I, Jain V, Binet J L, Hillmen P, Byrd J, Albitar M, Brettman L, Santabarbara P, Wacker B, Rai K R. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study.  Blood. 2002;  99 3554-3561
    Search in Google Scholar
  • 18 Keating M J, O’Brien S, Albitar M, Lerner S, Plunkett W, Giles F, Andreeff M, Cortes J, Faderl S, Thomas D, Koller C, Wierda W, Detry M A, Lynn A, Kantarjian H. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia.  J Clin Oncol. 2005;  23 4079-4088
    Search in Google Scholar
  • 19 Leandro M J, Cambridge G, Ehrenstein M R, Edwards J C. Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis.  Arthritis Rheum. 2006;  54 613-620
    Search in Google Scholar
  • 20 Listing J, Strangfeld A, Kary S, Rau R, Hinueber U von, Stoyanova-Scholz M, Gromnica-Ihle E, Antoni C, Herzer P, Kekow J, Schneider M, Zink A. Infections in patients with rheumatoid arthritis treated with biologic agents.  Arthritis Rheum. 2005;  52 3403-3412
    Search in Google Scholar
  • 21 Lundin J, Kimby E, Björkholm M, Broliden P A, Celsing F, Hjalmar V, Mollgard L, Rebello P, Hale G, Waldmann H, Mellstedt H, Österborg A. Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL).  Blood. 2002;  100 768-773
    Search in Google Scholar
  • 22 Malek S K, Obmann M A, Gotoff R A, Foltzer M A, Hartle J E, Potdar S. Campath-1H induction and the incidence of infectious complications in adult renal transplantation.  Transplantation. 2006;  81 17-20
    Search in Google Scholar
  • 23 Marty F M, Lee S J, Fahey M M, Alyea E P, Soiffer R J, Antin J H, Baden L R. Infliximab use in patients with severe graft-versus-host disease and other emerging risk factors of non-Candida invasive fungal infections in allogeneic hematopoietic stem cell transplant recipients: a cohort study.  Blood. 2003;  102 2768-2776
    Search in Google Scholar
  • 24 Montillo M, Tedeschi A, O’Brien S, Di Raimondo F, Lerner S, Ferrajoli A, Morra E, Keating M J. Phase II study of cladribine and cyclophosphamide in patients with chronic lymphocytic leukemia and prolymphocytic leukemia.  Cancer. 2003;  97 114-120
    Search in Google Scholar
  • 25 Paterson D L, Ndirangu M, Kwak E J, Husain S, Kusne S, Marcos A, Shapiro R, Eghtesad B, Patel K, Abu-Elmagd K, Bond G, McCurry K, Fung J. Opportunistic infections in solid-organ transplant recipients pre-treated with alemtuzumab.  44th Interscience Conference on Antimicrobial Agents and Chemotherapy 2004, American Society for Microbiology. Abstract #K-1427
  • 26 Pfreundschuh M, Trümper L, Österborg A, Pettengell R, Trneny M, Imrie K, Ma D, Gill D, Walewski J, Zinzani P L, Stahel R, Kvaloy S, Shpilberg O, Jaeger U, Hansen M, Lehtinen T, Lopez-Guillermo A, Corrado C, Scheliga A, Milpied N, Mendila M, Rashford M, Kuhnt E, Loeffler M. for the MabThera International Trial (MInT) Group . CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group.  Lancet Oncol. 2006;  7 379-391
    Search in Google Scholar
  • 27 Ponticelli C, Yussim A, Cambi V, Legendre C, Rizzo G, Salvadori M, Kahn D, Kashi H, Salmela K, Fricke L, Heemann U, Garcia-Martinez J, Lechler R, Prestele H, Girault D. Simulect Phase IV Study Group . A randomized, double-blind trial of basiliximab immunoprophylaxis plus triple therapy in kidney transplant recipients.  Transplantation. 2001;  72 1261-1267
    Search in Google Scholar
  • 28 Rai K R, Peterson B L, Appelbaum F R, Kolitz J, Elias L, Shepherd L, Hines J, Threatte G A, Larson R A, Cheson B D, Schiffer C A. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia.  N Engl J Med. 2000;  343 1750-1757
    Search in Google Scholar
  • 29 Rutgeerts P, Sandborn W J, Feagan B G, Reinisch W, Olson A, Johanns J, Travers S, Rachmilewitz D, Hanauer S B, Lichtenstein G R, Villiers W J, Present D de, Sands B E, Colombel J F. Infliximab for induction and maintenance therapy for ulcerative colitis.  N Engl J Med. 2005;  353 2462-2476
    Search in Google Scholar
  • 30 Schiff M H, Burmester G R, Kent J M, Pangan A L, Kupper H, Fitzpatrick S B, Donovan C. Safety analyses of adalimumab (Humira) in global clinical trials and US postmarketing surveillance of patients with rheumatoid arthritis.  Ann Rheum Dis. 2006;  65 889-894
    Search in Google Scholar
  • 31 Schulz H, Klein S K, Rehwald U, Reiser M, Hinke A, Knauf W U, Aulitzky W E, Hensel M, Herold M, Huhn D, Hallek M, Diehl V, Engert A. German CLL Study Group . Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia.  Blood. 2002;  100 3115-3120
    Search in Google Scholar
  • 32 Silveira F P, Marcos A, Kwak E J, Husain S, Shapiro R, Thai N, McCurry K R, Abu-Elmagd K, Paterson D L. Bloodstream infections in organ transplant recipients receiving alemtuzumab: No evidence of occurrence of organisms typically associated with profound T cell depletion.  J Infect. 2006;  [Epub ahead of print]
    Search in Google Scholar
  • 33 Takada K, Danning C L, Kuroiwa T, Schlimgen R, Tassiulas I O, Davis J C, Yarboro C H, Fleisher T A, Boumpas D T, Illei G G. Lymphocyte depletion with fludarabine in patients with psoriatic arthritis: clinical and immunological effects.  Ann Rheum Dis. 2003;  62 1112-1115
    Search in Google Scholar
  • 34 Tam C S, Wolf M M, Januszewicz E H, Grigg A P, Prince H M, Westerman D, Seymour J F. A new model for predicting infectious complications during fludarabine-based combination chemotherapy among patients with indolent lymphoid malignancies.  Cancer. 2004;  101 2042-2049
    Search in Google Scholar
  • 35 Tam C S, Seymour J F, Brown M, Campbell P, Scarlett J, Underhill C, Ritchie D, Bond R, Grigg A P. Early and late infectious consequences of adding rituximab to fludarabine and cyclophosphamide in patients with indolent lymphoid malignancies.  Haematologica. 2005;  90 700-702
    Search in Google Scholar
  • 36 Thursky K A, Worth L J, Seymour J F, Miles Prince H, Slavin M A. Spectrum of infection, risk and recommendations for prophylaxis and screening among patients with lymphoproliferative disorders treated with alemtuzumab.  Br J Haematol. 2006;  132 3-12
    Search in Google Scholar
  • 37 Tsiodras S, Samonis G, Keating M J, Kontoyiannis D P. Infection and immunity in chronic lymphocytic leukemia.  Mayo Clin Proc. 2000;  75 1039-1054
    Search in Google Scholar
  • 38 Wallis R S, Broder M S, Wong J Y, Hanson M E, Beenhouwer D O. Granulomatous infectious diseases associated with tumor necrosis factor antagonists.  Clin Infect Dis. 2004;  38 1261-1265
    Search in Google Scholar
  • 39 Wallis R S, Broder M, Wong J, Beenhouwer D. Granulomatous infections due to tumor necrosis factor blockade: correction.  Clin Infect Dis. 2004;  39 1254-1255
    Search in Google Scholar
  • 40 Wendtner C M, Ritgen M, Schweighofer C D, Fingerle-Rowson G, Campe H, Jäger G, Eichhorst B, Busch R, Diem H, Engert A, Stilgenbauer S, Döhner H, Kneba M, Emmerich B, Hallek M. German CLL Study Group (GCLLSG) . Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission -experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG).  Leukemia. 2004;  18 1093-1101
    Search in Google Scholar
  • 41 Westhoff T H, Jochimsen F, Schmittel A, Stoffler-Meilicke M, Schafer J H, Zidek W, Gerlich W H, Thiel E. Fatal hepatitis B virus reactivation by an escape mutant following rituximab therapy.  Blood. 2003;  102 1930
    Search in Google Scholar

Prof. Dr. G. Maschmeyer

Klinikum Ernst von Bergmann
Medizinische Klinik
Abt. Hämatologie und Onkologie

Charlottenstraße 72

14467 Potsdam

Phone: 03 31/2 41 60 01

Fax: 03 31/2 41 60 00

Email: gmaschmeyer@klinikumevb.de