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Neuropediatrics 2006; 37(2): 102-106
DOI: 10.1055/s-2006-923981
Short Communication

Georg Thieme Verlag KG Stuttgart · New York

Movement Disorders Induced by Gastrointestinal Drugs: Two Paediatric Cases

J. Elzinga-Huttenga1 , Y. Hekster2 , A. Bijl3 , J. Rotteveel1
  • 1Department of Paediatric Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
  • 2Department of Clinical Pharmacy, University Medical Centre St Radboud, Nijmegen, The Netherlands
  • 3Netherlands Pharmacovigilance Centre, Lareb, ‘s-Hertogenbosch, The Netherlands
Further Information

Publication History

Received: May 3, 2005

Accepted after Revision: February 6, 2006

Publication Date:
14 June 2006 (online)

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Abstract

A number of frequently prescribed gastrointestinal drugs can cause movement disorders in children, as well as in adults. In our centre for paediatric neurology, we saw a 3-year-old girl with abnormal movements mostly of the legs with an inner restlessness (akathisia) while using cisapride. Another patient, a 17-year-old male, developed a hemiballism (a fierce movement of one arm and shoulder with a hurling appearance) while using ranitidine for gastric distress. In both children, the movement disorder disappeared after discontinuing the drug. The pathophysiological mechanisms of these drug-induced movement disorders might be related to the central function of histamine in the developing brain. These cases illustrate the importance of being alert for possible drug-induced events early in the process of diagnosing abnormal movement disorders.

Key words

Movement disorder - drug - gastrointestinal - H2 receptor antagonists - cisapride - adverse drug reactions

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MD, PhD J. Rotteveel

Department of Paediatric Neurology
University Medical Centre St Radboud
Geert Grooteplein 10

P. O. Box 9101

6500 HB Nijmegen

The Netherlands

Email: j.rotteveel@cukz.umcn.nl