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Aktuelle Neurologie 2006; 33(4): 218-231
DOI: 10.1055/s-2005-915380
Kognitive Neurologie
© Georg Thieme Verlag KG Stuttgart · New York

Zerebrale Hemisphärenlateralität der Sprachlautwahrnehmung: Klinische und funktionell-bildgebende Befunde

Functional Neuroanatomy of Speech Sound Perception: Clinical and Imaging DataH.  Ackermann1 , I.  Hertrich1 , W.  Lutzenberger2 , K.  Mathiak3
  • 1Abteilung Allgemeine Neurologie, Hertie Institut für Klinische Hirnforschung, Universität Tübingen
  • 2MEG Zentrum, Universität Tübingen
  • 3Klinik für Psychiatrie und Psychotherapie, Rheinisch-Westfälische Technische Hochschule Aachen
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Publication Date:
24 January 2006 (online)

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Zusammenfassung

Die „core functions” sprachlicher Kommunikation, d. h. die Fähigkeit, phonologisch und syntaktisch wohlgeformte Sätze zu bilden und zu verstehen, sind zumindest bei rechtshändigen erwachsenen Menschen vorwiegend an die linke Hirnhälfte gebunden. Unter anderem dürften sich im Bereich der sprachdominanten Hemisphäre auch auditive Wortformen, d. h. die abstrakte Lautstruktur der Einträge des mentalen Lexikons, repräsentiert finden. Demgegenüber wird auf der Grundlage klinischer Daten eine weitgehend bilateral-symmetrische Verarbeitung der akustischen Korrelate der Konsonanten und Vokale einer Sprache (linguistische „information bearing elements”) im Bereich des Temporallappens angenommen. Dieses traditionelle neurolinguistische Modell beinhaltet somit eine strikte funktionell-neuroanatomische Trennung der zentral-auditiven und der linguistisch-kategorialen Ebene der Sprachlautwahrnehmung. Neuere klinische, psychoakustische und funktionell-bildgebende Befunde erfordern jedoch eine Erweiterung dieses Konzept in wenigstens zwei Hinsichten: (a) Schon auf der Ebene der auditiven Mismatch-Antworten, die als elektrophysiologisches Korrelat sensorischer Gedächtnisleistungen gelten, bilden sich phonetisch-linguistische Strukturen ab, und es zeigt sich ein Lateralitätseffekt der Verarbeitung von Sprachlauten und Silben („prälexikalische Inputrepräsentationen”) zugunsten der linken Hirnhälfte. (b) Neben der Hörrinde beider Hirnhälften und dem posterioren perisylviischen Kortex der sprachdominanten Hemisphäre scheinen unter bestimmten Bedingungen auch inferior-dorsolaterale Anteile des linken Frontalhirns und die rechte Kleinhirnhemisphäre an der Sprachlautwahrnehmung beteiligt zu sein und insbesondere Dauerparameter des akustischen Sprachsignals zu enkodieren. Psychoakustische und elektrophysiologische Befunde weisen auf eine effizientere „Auflösung” der Zeitstruktur sprachlicher und nichtsprachlicher auditiver Signale im Bereich der linken Hirnhälfte hin. Vor diesem Hintergrund dürften zumindest einige Lateralitätseffekte der Sprachlautwahrnehmung domänübergreifende (supramodulare) Operationen widerspiegeln. Im Verlauf der Evolution menschlicher Lautsprache könnte diese funktionelle Asymmetrie zentral-auditiver Verarbeitung über einen „Schneeballeffekt” zu Lateralitätseffekten kognitiver Komponenten der Sprachverarbeitung wie des Wortformlexikons geführt haben, die dann „top down” auch Seitunterschiede der Enkodierung zeit-unkritischer Parameter des akustischen Signals hervorrufen.

Abstract

Clinical and experimental data indicate that the „core functions” of speech communication, i. e., the ability to produce and to comprehend phonologically and syntactically well-formed sentences, are bound primarily to the left hemisphere of the brain, at least in right-handed adult individuals. Among others, the language-dominant perisylvian area seems predominantly to process and/or to store abstract representations of the sound structure of lexical items (auditory word forms). By contrast, the superior aspects of both temporal lobes have been assumed to subserve the encoding of the acoustic correlates of the consonant and vowel sounds of a language (linguistic „information bearing elements” of the speech signal). As a consequence, these findings suggest a strict functional-neuroanatomic separation of the central-auditory and the linguistic-categorical level of speech perception. More recent functional-imaging data call, however, for a revision of this concept in at least two regards: (a) Auditory mismatch-responses, considered an electrophysiological correlate of sensory memory operations, reflect phonetic-linguistic data structures and may display left-hemisphere laterality effects during the processing of speech sounds and syllables („prelexical input representations”). (b) Besides bilateral acoustic cortex and posterior parts of the language-dominant perisylvian area, inferior-dorsolateral regions of the left frontal lobe and superior aspects of the right cerebellar hemisphere may, under specific conditions, participate in the encoding of durational parameters of the acoustic speech signal. Psychoacoustic and electrophysiological data suggest the left hemisphere to be more efficient in resolving temporal aspects of complex speech and nonspeech auditory signals. At least some laterality effects of speech sound processing, thus, might reflect side-differences of general-auditory operations. As a consequence, these functional asymmetries of central-auditory processing might have given rise via a „snowball effect” to left-hemisphere lateralization of higher-order (cognitive) aspects of speech perception such as the phonological component of the mental lexicon.

Literatur

  • 1 Critchley M. Dax's law.  Int J Neurol. 1964;  4 199-206
    PubMedGoogle Scholar
  • 2 Broca P. Remarques sur le siège de la faculté du langage articulé, suivies d'une observation d'aphémie (perte de la parole).  Bulletins de la Société Anatomique de Paris. 1861;  36 330-357
    PubMedGoogle Scholar
  • 3 Broca P. Sur le siège de la faculté du langage articulé.  Bulletins de la Société d'Anthropologie de Paris. 1865;  6 377-393
    PubMedGoogle Scholar
  • 4 Wernicke C. Der aphasische Symptomencomplex. Breslau; Cohn & Weigert 1874
    Google Scholar
  • 5 Caplan D. Neurolinguistics and Linguistic Aphasiology. An Introduction. Cambridge; Cambridge University Press 1987 (Cambridge Studies in Speech Science and Communication)
    Google Scholar
  • 6 Zaidel E. Language in the right hemisphere. In: Benson DF, Zaidel E (eds) The Dual Brain. Hemispheric Specialization in Humans. (UCLA Forum in Medical Sciences, No. 26). New York; Guilford Press 1985: 205-231
    Google Scholar
  • 7 Ackermann H, Hertrich I, Ziegler W. Prosodische Störungen bei neurologischen Erkrankungen: eine Literaturübersicht.  Fortschr Neurol Psychiat. 1993;  61 241-253
    PubMedGoogle Scholar
  • 8 Ackermann H, Hertrich I, Grodd W, Wildgruber D. „Das Hören von Gefühlen”: funktionell-neuroanatomische Grundlagen der Verarbeitung affektiver Prosodie.  Akt Neurol. 2004;  31 449-460
    Article in Thieme ConnectPubMedGoogle Scholar
  • 9 Lichtheim L. On aphasia.  Brain. 1885;  7 433-485
    PubMedGoogle Scholar
  • 10 Lichtheim L. Ueber Aphasie.  Deutsches Archiv fuer klinische Medicin. 1885;  36 204-268
    PubMedGoogle Scholar
  • 11 Ackermann H, Mathiak K. Symptomatologie, pathologisch-anatomische Grundlagen und Pathomechanismen zentraler Hörstörungen (reine Worttaubheit, auditive Agnosie, Rindentaubheit): eine Literaturübersicht.  Fortschr Neurol Psychiat. 1999;  67 509-523
    PubMedGoogle Scholar
  • 12 Poeck K. Temporal lobe syndromes. In: Vinken PJ, Bruyn GW, Klawans HL (eds) Clinical Neuropsychology. (Handbook of Clinical Neurology, Vol. 45, Revised Series 1). Amsterdam; Elsevier 1985: 43-48
    Google Scholar
  • 13 Friederici A D, Cramon D Y von. Neurobiologische Grundlagen des Sprachverstehens. In: Friederici AD (Hrsg) Sprachrezeption. (Enzyklopädie der Psychologie, Themenbereich C, Serie III, Band 2). Göttingen; Hogrefe 1999: 307-349
    Google Scholar
  • 14 Liberman A M. Speech. A Special Code. Cambridge; MIT Press 1996
    Google Scholar
  • 15 Ladefoged P, Maddieson I. The Sounds of the World's Languages. Oxford; Blackwell 1997
    Google Scholar
  • 16 Suga N. Multi-function theory for cortical processing of auditory information: implications of single-unit and lesion data for future research.  J Comp Physiol [A]. 1994;  175 135-144
    CrossrefPubMedGoogle Scholar
  • 17 Kuhl P K. Early language acquisition: cracking the speech code.  Nat Rev Neurosci. 2004;  5 831-843
    PubMedGoogle Scholar
  • 18 Oller D K. The Emergence of the Speech Capacity. Mahwah; Erlbaum 2000
    Google Scholar
  • 19 MacNeilage P F, Davis B L. Motor mechanisms in speech ontogeny: phylogenetic, neurobiological and linguistic implications.  Curr Opin Neurobiol. 2001;  11 696-700
    CrossrefPubMedGoogle Scholar
  • 20 Jusczyk P W. The Discovery of Spoken Language. Cambridge; MIT Press 1997
    Google Scholar
  • 21 Sams M, Aulanko R, Aaltonen O, Näätänen R. Event-related potentials to infrequent changes in synthesized phonetic stimuli.  J Cogn Neurosci. 1990;  2 344-357
    PubMedGoogle Scholar
  • 22 Ackermann H, Gräber S, Hertrich I, Daum I. Categorical speech perception in cerebellar disorders.  Brain Lang. 1997;  60 323-331
    CrossrefPubMedGoogle Scholar
  • 23 Ackermann H, Mathiak K, Wildgruber D. et al .Neurobiologische Grundlagen der Sprachlautwahrnehmung: Klinische und funktionell-bildgebende Befunde. In: Müller HM, Rickheit G (Hrsg) Neurokognition der Sprache. Tübingen; Stauffenburg 2004: 167-189
    Google Scholar
  • 24 Kluender K R, Diehl R L, Killeen P R. Japanese quail can learn phonetic categories.  Science. 1987;  237 1195-1197
    PubMedGoogle Scholar
  • 25 Kuhl P K, Miller J D. Speech perception by the chinchilla: voiced-voiceless distinction in alveolar plosive consonants.  Science. 1975;  190 69-72
    PubMedGoogle Scholar
  • 26 Kuhl P K, Padden D M. Enhanced discriminability at the phonetic boundaries for the place feature in macaques.  J Acoust Soc Am. 1983;  73 1003-1010
    CrossrefPubMedGoogle Scholar
  • 27 Eimas P D, Siqueland E R, Jusczyk P, Vigorito J. Speech perception in infants.  Science. 1971;  171 303-306
    CrossrefPubMedGoogle Scholar
  • 28 Simos P G, Breier J I, Zouridakis G, Papanicolaou A C. Magnetic fields elcited by a tone onset time continuum in humans.  Brain Res Cogn Brain Res. 1998;  6 285-294
    PubMedGoogle Scholar
  • 29 Massaro D W. Psychological aspects of speech perception: implications for research and theory. In: Gernsbacher MA (ed) Handbook of Psycholinguistics. San Diego; Academic Press 1994: 219-263
    Google Scholar
  • 30 Bregman A S. Auditory Scene Analysis. The Perceptual Organization of Sound. Cambridge; MIT Press 1990
    Google Scholar
  • 31 Geschwind N. Disconnexion syndromes in animals and man.  Brain. 1965;  88 237-294, 585 - 644
    CrossrefPubMedGoogle Scholar
  • 32 Schacter D L. Priming and multiple memory systems: perceptual mechanisms of implicit memory.  J Cogn Neurosci. 1992;  4 244 -256
    PubMedGoogle Scholar
  • 33 Griffiths T D, Warren J D. The planum temporale as a computational hub.  TINS. 2002;  25 348-353
    CrossrefPubMedGoogle Scholar
  • 34 Shankweiler D, Studdert-Kennedy M. Identification of consonants and vowels presented to left and right ears.  Q J Exp Psychol. 1967;  19 59-63
    PubMedGoogle Scholar
  • 35 Studdert-Kennedy M, Shankweiler D. Hemispheric specialization for speech perception.  J Acoust Soc Am. 1970;  48 579-594
    PubMedGoogle Scholar
  • 36 Molfese D L, Erwin R J. Intrahemispheric differentiation of vowels: principal component analysis of auditory evoked responses to computer-synthesized vowel sounds.  Brain Lang. 1981;  13 333-344
    CrossrefPubMedGoogle Scholar
  • 37 Godfrey J J. Perceptual difficulty and the right ear advantage for vowels.  Brain Lang. 1974;  1 323-335
    CrossrefPubMedGoogle Scholar
  • 38 Weiss M, House A S. Perception of dichotically presented vowels.  J Acoust Soc Am. 1973;  53 51-58
    CrossrefPubMedGoogle Scholar
  • 39 Dewson J H. Preliminary evidence of hemispheric asymmetry of auditory function in monkeys. In: Harnad S, Doty RW, Goldstein L et al (eds) Lateralization in the Nervous System. New York; Academic Press 1977: 63-71
    Google Scholar
  • 40 Petersen M R, Beecher M D, Zoloth S R. et al . Neural lateralization of species-specific vocalizations by Japanese macaques (Macaca fuscata).  Science. 1978;  202 324-326
    PubMedGoogle Scholar
  • 41 Näätänen R, Winkler I. The concept of auditory stimulus representation in cognitive neuroscience.  Psychol Bull. 1999;  125 826 -859
    CrossrefPubMedGoogle Scholar
  • 42 Tiitinen H, May P, Reinikainen K, Näätänen R. Attentive novelty detection in humans is governed by pre-attentive sensory memory.  Nature. 1994;  372 90-92
    PubMedGoogle Scholar
  • 43 Dehaene-Lambertz G, Dupoux E, Gout A. Electrophysiological correlates of phonological processing: a cross-linguistic study.  J Cogn Neurosci. 2000;  12 635-647
    CrossrefPubMedGoogle Scholar
  • 44 Eulitz C, Diesch E, Pantev C. et al . Magnetic and electric brain activity evoked by the processing of tone and vowel stimuli.  J Neurosci. 1995;  15 2748-2755
    PubMedGoogle Scholar
  • 45 Diesch E, Eulitz C, Hampson S, Ross B. The neurotopography of vowels as mirrored by evoked magnetic field measurements.  Brain Lang. 1996;  53 143-168
    CrossrefPubMedGoogle Scholar
  • 46 Tiitinen H, Sivonen P, Alku P. et al . Electromagnetic recordings reveal latency differences in speech and tone processing in humans.  Brain Res Cogn Brain Res. 1999;  8 355-363
    PubMedGoogle Scholar
  • 47 Miki K, Watanabe S, Kakigi R. Interaction between auditory and visual stimulus relating to the vowel sounds in the auditory cortex in humans: a magnetoencephalographic study.  Neurosci Lett. 2004;  357 199-202
    CrossrefPubMedGoogle Scholar
  • 48 Kuriki S, Murase M. Neuromagnetic study of the auditory responses in right and left hemispheres of the human brain evoked by pure tones and speech sounds.  Exp Brain Res. 1989;  77 127-134
    PubMedGoogle Scholar
  • 49 Alku P, Sivonen P, Palomaki K, Tiitinen H. The periodic structure of vowel sounds is reflected in human electromagnetic brain responses.  Neurosci Lett. 2001;  298 25-28
    CrossrefPubMedGoogle Scholar
  • 50 Eulitz C, Obleser J, Lahiri A. Intra-subject replication of brain magnetic activity during the processing of speech sounds.  Brain Res Cogn Brain Res. 2004;  19 82-91
    PubMedGoogle Scholar
  • 51 Poeppel D, Phillips C, Yellin E. et al . Processing of vowels in supratemporal auditory cortex.  Neurosci Lett. 1997;  221 145-148
    CrossrefPubMedGoogle Scholar
  • 52 Obleser J, Eulitz C, Lahiri A, Elbert T. Gender differences in functional hemispheric asymmetry during processing of vowels as reflected by the human brain magnetic response.  Neurosci Lett. 2001;  314 131-134
    CrossrefPubMedGoogle Scholar
  • 53 Vihla M, Lounasmaa O V, Salmelin R. Cortical processing of change detection: dissociation between natural vowels and two-frequency complex tones.  Proc Natl Acad Sci USA. 2000;  97 10590-10594
    CrossrefPubMedGoogle Scholar
  • 54 Kaukoranta E, Hari R, Lounasmaa O V. Responses of the human auditory cortex to vowel onset after fricative consonants.  Exp Brain Res. 1987;  69 19-23
    CrossrefPubMedGoogle Scholar
  • 55 Diesch E, Luce T. Topographic and temporal indices of vowel spectral envelope extraction in the human auditory cortex.  J Cogn Neurosci. 2000;  12 878-893
    CrossrefPubMedGoogle Scholar
  • 56 Obleser J, Elbert T, Lahiri A, Eulitz C. Cortical representation of vowels reflects acoustic dissimilarity determined by formant frequencies.  Brain Res Cogn Brain Res. 2003;  15 207-213
    PubMedGoogle Scholar
  • 57 Obleser J, Eulitz C, Lahiri A. Magnetic brain response mirrors extraction of phonological features from spoken vowels.  J Cogn Neurosci. 2004;  16 31-39
    CrossrefPubMedGoogle Scholar
  • 58 Jaramillo M, Ilvonen T, Kujala T. et al . Are different kinds of acoustic features processed differently for speech and non-speech sounds?.  Brain Res Cogn Brain Res. 2001;  12 459-466
    PubMedGoogle Scholar
  • 59 Savela J, Kujala T, Tuomainen J. et al . The mismatch negativity and reaction time as indices of the perceptual distance between the corresponding vowel of two related languages.  Brain Res Cogn Brain Res. 2003;  16 250-256
    PubMedGoogle Scholar
  • 60 Jacobsen T. Mismatch negativity to frequency changes: no evidence from human event-related brain potentials for categorical speech processing of complex tones resembling vowel formant structure.  Neurosci Lett. 2004;  362 204-208
    CrossrefPubMedGoogle Scholar
  • 61 Jacobsen T, Schröger E, Alter K. Pre-attentive perception of vowel phonemes from variable speech stimuli.  Psychophysiology. 2004;  41 654-659
    CrossrefPubMedGoogle Scholar
  • 62 Jacobsen T, Schröger E, Sussman E. Pre-attentive categorization of vowel formant structure in complex tones.  Brain Res Cogn Brain Res. 2004;  20 473-479
    PubMedGoogle Scholar
  • 63 Aaltonen O, Tuomainen J, Laine M, Niemi P. Event-related potentials and discrimination of steady-state vowels within phoneme categories: a preliminary study.  Scand J Logoped Phonet. 1992;  17 107-112
    PubMedGoogle Scholar
  • 64 Maiste A, Wiens A, Hunt M, Picton T. Event-related potentials and the categorical perception of speech sounds.  Ear Hear. 1995;  16 68-90
    PubMedGoogle Scholar
  • 65 Sharma A, Kraus N, McGee T. et al . Acoustic versus phonetic representation of speech as reflected by the mismatch negativity event-related potential.  Electroencephalogr Clin Neurophysiol. 1993;  88 64-71
    PubMedGoogle Scholar
  • 66 Näätänen R, Lehtokoski A, Lennes M. et al . Language-specific phoneme representations revealed by electric and magnetic brain responses.  Nature. 1997;  385 432-434
    CrossrefPubMedGoogle Scholar
  • 67 Shestakova A, Brattico E, Huotilainen M. et al . Abstract phoneme representations in the left temporal cortex: magnetic mismatch negativity study.  NeuroReport. 2002;  13 1813-1816
    PubMedGoogle Scholar
  • 68 Winkler I, Lehtokoski A, Alku P. et al . Pre-attentive detection of vowel contrasts utilizes both phonetic and auditory memory representations.  Brain Res Cogn Brain Res. 1999;  7 357-369
    PubMedGoogle Scholar
  • 69 Rinne T, Alho K, Alku P. et al . Analysis of speech sounds is left-hemisphere predominant at 100 - 150 ms after sound onset.  NeuroReport. 1999;  10 1113-1117
    PubMedGoogle Scholar
  • 70 Näätänen R. The perception of speech sounds by the human brain as reflected by the mismatch negativity (MMN) and its magnetic equivalent (MMNm).  Psychophysiology. 2001;  38 1-21
    CrossrefPubMedGoogle Scholar
  • 71 Molfese D L. Neuroelectrical correlates of categorical speech perception in adults.  Brain Lang. 1978;  5 25-35
    CrossrefPubMedGoogle Scholar
  • 72 Molfese D L. Hemispheric specialization for temporal information: implications for the perception of voicing cues during speech perception.  Brain Lang. 1980;  11 285-299
    CrossrefPubMedGoogle Scholar
  • 73 Molfese D L, Hess T M. Hemispheric specialization for VOT perception in the preschool child.  J Exp Child Psychol. 1978;  26 71-84
    CrossrefPubMedGoogle Scholar
  • 74 Poeppel D, Yellin E, Phillips C. et al . Task-induced asymmetry of the auditory evoked M100 neuromagnetic field elicited by speech sounds.  Brain Res Cogn Brain Res. 1996;  4 231-242
    CrossrefPubMedGoogle Scholar
  • 75 Simos P G, Diehl R L, Breier J I. et al . MEG correlates of categorical perception of a voice onset time continuum in humans.  Brain Res Cogn Brain Res. 1998;  7 215-219
    PubMedGoogle Scholar
  • 76 Simos P G, Molfese D L. Electrophysiological responses from a temporal order continuum in the newborn infant.  Neuropsychologia. 1997;  35 89-98
    CrossrefPubMedGoogle Scholar
  • 77 Papanicolaou A C, Castillo E, Breier J I. et al . Differential brain activation patterns during perception of voice and tone onset time series: a MEG study.  NeuroImage. 2003;  18 448-459
    CrossrefPubMedGoogle Scholar
  • 78 Ackermann H, Lutzenberger W, Hertrich I. Hemispheric lateralization of the neural encoding of temporal speech features: a whole-head magnetencephalography study.  Brain Res Cogn Brain Res. 1999;  7 511-518
    PubMedGoogle Scholar
  • 79 Phillips C, Pellathy T, Marantz A. et al . Auditory cortex accesses phonological categories: an MEG mismatch study.  J Cogn Neurosci. 2000;  12 1038-1055
    CrossrefPubMedGoogle Scholar
  • 80 Wood C C, Goff W R, Day R S. Auditory evoked potentials during speech perception.  Science. 1971;  173 1248-1251
    PubMedGoogle Scholar
  • 81 Morrell L K, Salamy J G. Hemispheric asymmetry of electrocortical responses to speech stimuli.  Science. 1971;  174 164-166
    PubMedGoogle Scholar
  • 82 Molfese D L, Schmid A. An auditory evoked potential study of consonant perception in different vowel environments.  Brain Lang. 1983;  18 57-70
    CrossrefPubMedGoogle Scholar
  • 83 Molfese D L. Left hemisphere sensitivity to consonant sounds not displayed by the right hemisphere: electrophysiological correlates.  Brain Lang. 1984;  22 109-127
    CrossrefPubMedGoogle Scholar
  • 84 Molfese D L, Buhrke R A, Wang S L. The right hemisphere and temporal processing of consonant transition durations: electrophysiological correlates.  Brain Lang. 1985;  26 49-62
    CrossrefPubMedGoogle Scholar
  • 85 Gage N, Poeppel D, Roberts T PL, Hickock G. Auditory evoked M100 reflects onset acoustics of speech sounds.  Brain Res Cogn Brain Res. 1998;  814 236-239
    CrossrefPubMedGoogle Scholar
  • 86 Obleser J, Lahiri A, Eulitz C. Auditory-evoked magnetic field codes place of articulation in timing and topography around 100 milliseconds postsyllable onset.  NeuroImage. 2003;  20 1839-1847
    CrossrefPubMedGoogle Scholar
  • 87 Obleser J, Rockstroh B, Eulitz C. Gender differences in hemispheric asymmetry of syllable processing: left-lateralized magnetic N100 varies with syllable categorization in females.  Psychophysiology. 2004;  41 783-788
    CrossrefPubMedGoogle Scholar
  • 88 Kraus N, Cheour M. Speech sound representation in the brain.  Audiol Neurootol. 2000;  5 140-150
    CrossrefPubMedGoogle Scholar
  • 89 Diesch E, Luce T. Magnetic mismatch fields elicited by vowels and consonants.  Exp Brain Res. 1997;  116 139-152
    PubMedGoogle Scholar
  • 90 Sams M, Aulanko R, Aaltonen O, Näätänen R. Event-related potentials to infrequent changes in synthesized phonetic stimuli.  J Cogn Neurosci. 1990;  2 344-357
    PubMedGoogle Scholar
  • 91 Sharma A, Dorman M F. Cortical auditory evoked potential correlates of categorical perception of voice-onset time.  J Acoust Soc Am. 1999;  106 1078-1083
    CrossrefPubMedGoogle Scholar
  • 92 Mathiak K, Hertrich I, Lutzenberger W, Ackermann H. Preattentive processing of consonant-vowel syllables at the supratemporal plane: a whole-head magnetencephalography study.  Brain Res Cogn Brain Res. 1999;  8 251-257
    PubMedGoogle Scholar
  • 93 Mathiak K, Hertrich I, Lutzenberger W, Ackermann H. Encoding of temporal speech features (formant transients) during binaural and dichotic stimulus application: a whole-head magnetencephalography study.  Brain Res Cogn Brain Res. 2000;  10 125-131
    PubMedGoogle Scholar
  • 94 Hertrich I, Mathiak K, Lutzenberger W, Ackermann H. Hemispheric lateralization of the processing of consonant-vowel syllables (formant transitions): effects of stimulus characteristics and attentional demands on evoked magnetic fields.  Neuropsychologia. 2002;  40 1902-1917
    PubMedGoogle Scholar
  • 95 Ackermann H, Hertrich I, Lutzenberger W, Mathiak K. Cerebral organization of speech sound perception: hemispheric lateralization effects at the level of the supratemporal plane, the inferior dorsolateral frontal lobe and the cerebellum. In: König R, Heil P, Budinger E, Scheich H (eds) The Auditory Cortex. A Synthesis of Human and Animal Research. Mahwah; Erlbaum 2005: 181-200
    Google Scholar
  • 96 Poeppel D. A critical review of PET studies of phonological processing.  Brain Lang. 1996;  55 317-351
    CrossrefPubMedGoogle Scholar
  • 97 Binder J R, Frost J A, Hammeke T A. et al . Human temporal lobe activation by speech and nonspeech sounds.  Cereb Cortex. 2000;  10 512-528
    CrossrefPubMedGoogle Scholar
  • 98 Celsis P, Boulanouar K, Doyon B. et al . Differential fMRI responses in the left posterior superior temporal gyrus and left supramarginal gyrus to habituation and change detection in syllables and tones.  NeuroImage. 1999;  9 135-144
    CrossrefPubMedGoogle Scholar
  • 99 Jäncke L, Wüstenberg T, Scheich H, Heinze H J. Phonetic perception and the temporal cortex.  NeuroImage. 2002;  15 733-746
    CrossrefPubMedGoogle Scholar
  • 100 Tallal P, Miller S, Fitch R H. Neurobiological basis of speech: a case for the preeminence of temporal processing. In: Tallal P, Galaburda AM, Llinàs RR, Euler C von (eds) Temporal Information Processing in the Nervous System. Special Reference to Dyslexia and Dysphasia. (Annals of the New York Academy of Sciences, Vol. 682.) New York; The New York Academy of Sciences 1993: 27-47
    Google Scholar
  • 101 Ivry R B, Robertson L C. The Two Sides of Perception. Cambridge; MIT Press 1998
    Google Scholar
  • 102 Poeppel D. Pure word deafness and the bilateral processing of the speech code.  Cognitive Science. 2001;  25 679-693
    CrossrefPubMedGoogle Scholar
  • 103 Nicholls M ER. Temporal processing asymmetries between the cerebral hemispheres: evidence and implication.  Laterality. 1996;  1 97-137
    CrossrefPubMedGoogle Scholar
  • 104 Steinschneider M, Fishman Y I, Arezzo J C. Representation of the voice onset time (VOT) speech parameter in population responses within primary auditory cortex of the awake monkey.  J Acoust Soc Am. 2003;  114 307-321
    CrossrefPubMedGoogle Scholar
  • 105 Steinschneider M, Volkov I O, Noh M D. et al . Temporal encoding of the voice onset time phonetic parameter by field potentials recorded directly from human auditory cortex.  J Neurophysiol. 1999;  82 2346-2357
    PubMedGoogle Scholar
  • 106 Steinschneider M, Volkov I O, Fishman Y I. et al . Intracortical responses in human and monkey primary auditory cortex support a temporal processing mechanism for encoding of the voice onset time phonetic parameter.  Cereb Cortex. 2005;  15 170-186
    PubMedGoogle Scholar
  • 107 Sharma A, Marsh C M, Dorman M F. Relationship between N1 evoked potential morphology and the perception of voicing.  J Acoust Soc Am. 2000;  108 3030-3035
    CrossrefPubMedGoogle Scholar
  • 108 Liégeois-Chauvel C, Graaf J B de, Laguitton V, Chauvel P. Specialization of left auditory cortex for speech perception in man depends on temporal coding.  Cereb Cortex. 1999;  9 484-496
    CrossrefPubMedGoogle Scholar
  • 109 Ojemann G A. Brain organization for language from the perspective of electrical stimulation mapping.  Behav Brain Sci. 1983;  6 189-230
    PubMedGoogle Scholar
  • 110 Blumstein S E, Baker E, Goodglass H. Phonological factors in auditory comprehension in aphasia.  Neuropsychologia. 1977;  15 19-29
    CrossrefPubMedGoogle Scholar
  • 111 Blumstein S E, Cooper W E, Zurif E B, Caramazza A. The perception and production of voice-onset time in aphasia.  Neuropsychologia. 1977;  15 371-383
    CrossrefPubMedGoogle Scholar
  • 112 Fiez J A, Raichle M E, Miezin F M. et al . PET studies of auditory and phonological processing: effects of stimulus characteristics and task demands.  J Cogn Neurosci. 1995;  7 357-375
    PubMedGoogle Scholar
  • 113 Burton M W, Small S L, Blumstein S E. The role of segmentation in phonological processing: an fMRI investigation.  J Cogn Neurosci. 2000;  12 679-690
    CrossrefPubMedGoogle Scholar
  • 114 Ackermann H, Daum I. Neuropsychological deficits in cerebellar syndromes. In: Bédard MA, Agid Y, Chouinard S, Fahn S, Korczyn AD, Lespérance P (eds) Mental and Behavioral Dysfunction in Movement Disorders. Totowa; Humana Press 2003: 147-156
    Google Scholar
  • 115 Ackermann H, Mathiak K, Ivry R B. Temporal organization of „internal speech” as a basis for cerebellar modulation of cognitive functions.  Behav Cogn Neurosci Rev. 2004;  3 14-22
    CrossrefPubMedGoogle Scholar
  • 116 Mathiak K, Hertrich I, Grodd W, Ackermann H. Cerebellum and speech perception: a functional magnetic resonance imaging study.  J Cogn Neurosci. 2002;  14 902-912
    CrossrefPubMedGoogle Scholar
  • 117 Mathiak K, Hertrich I, Grodd W, Ackermann H. Discrimination of temporal information at the cerebellum: functional magnetic resonance imaging of nonverbal auditory memory.  NeuroImage. 2004;  21 154-162
    CrossrefPubMedGoogle Scholar
  • 118 Frauenfelder U H, Floccia C. Das Erkennen gesprochener Wörter. In: Friederici AD (Hrsg) Sprachrezeption. (Enzyklopädie der Psychologie, Themenbereich C, Serie III, Band 2.) Göttingen; Hogrefe 1999: 1-48
    Google Scholar
  • 119 Striedter G F. Principles of Brain Evolution. Sunderland; Sinauer Associates 2005
    Google Scholar

Prof. Dr. Hermann AckermannMA 

Abteilung Allgemeine Neurologie · Hertie Institut für Klinische Hirnforschung · Universität Tübingen

Hoppe-Seyler-Straße 3

72076 Tübingen

Email: hermann.ackermann@uni-tuebingen.de

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