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Horm Metab Res 2005; 37: 56-60
DOI: 10.1055/s-2005-861370
DOI: 10.1055/s-2005-861370
Review
© Georg Thieme Verlag KG Stuttgart · New YorkFunctional Abnormalities in Isolated Arteries from Goto-Kakizaki and Streptozotocin-treated Diabetic Rat Models
Further Information
Publication History
Received 15 December 2004
Accepted after Revision 2 February 2005
Publication Date:
25 May 2005 (online)
Abstract
Several different rat models have been developed for both type 1 and type 2 diabetes
with the aim of displaying specific traits of diabetes. For example, a review on nephropathy
associated with type 2 diabetes included 16 different rodent models [1]; new models are still being developed. The large number of different models developed
for different traits makes it difficult to choose the right model for a given study.
It is often a problem that the models are not sufficiently characterized, which makes
it easy to misinterpret data or even come to the wrong conclusions.
In this brief review, we will concentrate on the functional responses obtained in vitro from mesenteric arteries and aortic segments from rat models of diabetes. Since it
is beyond the scope of this review to overview all different rodent models of diabetes,
we will focus on two commonly used models of diabetes, namely the streptozotocin (STZ)-induced
type 1 diabetic rat model and the inbred type 2 diabetic Goto-Kakizaki (GK)-rat model.
Key words
Diabetes mellitus - Rat - Goto-Kakizaki - Streptozotocin
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Prof. C. Aalkjær
The Water and Salt Research Center, Institute of Physiology and Biophysics ·
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Phone: +45 8942 2804
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