Zusammenfassung
Die therapeutische Wirksamkeit von Apomorphin auf die Kardinalsymptome der Parkinson-Krankheit
ist bereits seit 120 Jahren bekannt. Seit Ende der 80er-Jahre wird die subkutane Injektion
von Apomorphin zu diagnostischen Zwecken eingesetzt. Der Apomorphintest dient der
Beurteilung der Effektivität einer dopaminergen Therapie sowie der Diagnoseüberprüfung
bei Patienten mit neu aufgetretenem oder atypisch verlaufendem Parkinson-Syndrom.
Der folgende Beitrag fasst die Anwendung des Apomorphintests im klinischen Alltag
sowie die Ergebnisse einer Metaanalyse zur diagnostischen Wertigkeit des Apomorphintests
zusammen.
Abstract
The therapeutical efficacy of apomorphine on the cardinal motor symptoms of Parkinson's
disease is well known since 120 years. By the late eighties the subcutaneous injection
of apomorphine was used for the first time in the assessment of parkinsonian patients.
Since then the apomorphine test is performed to determine dopaminergic responsiveness
as part of a pre-treatment assessment or in differential diagnosis of parkinsonian
syndromes. We summarize here the clinical management of the apomorphine test as well
as the results of a meta-analysis on the diagnostic use of apomorphine in parkinsonian
patients.
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Dr. med. Karla Eggert
Neurologische Klinik · Philipps-Universität Marburg
Rudolf-Bultmann-Straße 8
35039 Marburg
Email: eggert@med.uni-marburg.de
