Horm Metab Res 2004; 36(11/12): 811-821
DOI: 10.1055/s-2004-826168
Review
© Georg Thieme Verlag KG Stuttgart · New York

The Development of Beta-cell Mass: Recent Progress and Potential Role of GLP-1

D.  A.  Stoffers1
  • 1Division of Endocrinology, Diabetes and Metabolism, Department of Medicine and Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, USA
Further Information

Publication History

Received 17 August 2004

Accepted after revision 22 August 2004

Publication Date:
18 January 2005 (online)

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Abstract

Over the last decade, remarkable strides in incretin hormone biology have laid the foundation for our more recent appreciation that GLP-1 not only regulates mature β-cell function but also critically regulates β-cell differentiation, β-cell proliferation and β-cell survival. Dysregulated β-cell growth and function are central to the pathophysiology of both type 1 and type 2 diabetes. Thus, GLP-1 receptor agonists are being intensively developed for the treatment of human diabetes and are likely to become available to clinical use in the near future. A general overview of β-cell development will be provided, with particular emphasis on recent contributions to our understanding of pancreas and islet development during the embryonic, fetal and neonatal periods. The transcriptional hierarchy and extracellular signals governing events during these periods will be highlighted. Evidence suggesting a role for endogenous GLP-1 and GLP-1 receptor during β-cell development will be reviewed. Finally, the therapeutic potential for intervention with GLP1 receptor agonists during the neonatal period will be discussed.

References

D. A. Stoffers, M.D., Ph.D.

Clinical Research Building 611 B, Department of Medicine, University of Pennsylvania School of Medicine

415 Curie Boulevard · Philadelphia, Pennsylvania 19104-4399 · USA ·

Phone: +1 (215) 573-5413

Fax: +1 (215) 898-5408

Email: stoffers@mail.med.upenn.edu