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Exp Clin Endocrinol Diabetes 2004; 112(7): 364-372
DOI: 10.1055/s-2004-821027
Article

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Functional Parameters Before and After Parathyroidectomy: A Prospective, Randomized Long-Term Trial On Different Rat Strains

C. Hasse1 , M. Brune1 , W. Lorenz2 , P. Barth3 , W. Metzler4 , G. Breves4 , H. Sitter2
  • 1Department of Visceral, Thoracic and Vascular Surgery, Philipps-University Marburg, Marburg, Germany
  • 2Institute for Theoretical Surgery, Philipps-University Marburg, Marburg, Germany
  • 3Institute for Pathology, Philipps-University Marburg, Marburg, Germany
  • 4Institute for Physiology, University, Hannover, Germany
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Publikationsverlauf

Received: June 23, 2003 First decision: August 18, 2003

Accepted: December 8, 2003

Publikationsdatum:
07. Juli 2004 (online)

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Abstract

For clinical controls before and after parathyroidectomy and for evaluation of the function of transplants of parathyroid tissue, it is necessary to establish standard values of relevant laboratory parameters for donor and recipient animals as well as for different types of nutrition. Since no such data are yet available, it was the purpose to define such standards.

In a prospective randomized trial on 400 rats of the Dark Agouti (DA) and Lewis strain, different functional laboratory parameters such as total calcium, intact parathyroid hormone, phosphate, 1.25-dihydroxyvitamin D, and alkaline phosphatase were measured under a standard and low calcium diet over a period of 40 weeks. Two hundred of these animals underwent a parathyroidectomy four weeks after the beginning of the study and specimens were evaluated histologically.

For all eight different study groups normal values could be defined within tight limits for parameters which describe the function of the parathyroid gland or elements of calcium metabolism under different conditions. The optimal conditions for a transplantation model of parathyroid glands were established. Lewis-rats were identified as the ideal donor and DA rats as the better recipient animals. These data can serve as reference values for future studies on transplantation of the parathyroid without immunosuppression.

Key words

Functional parameters - parathyroidectomy - rats - prospective - randomized long-term trial

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