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Semin Respir Crit Care Med 2003; 24(5): 567-576
DOI: 10.1055/s-2004-815604
DOI: 10.1055/s-2004-815604
Miscellaneous Causes of Bronchiolitis: Inhalational, Infectious, Drug-Induced, and Idiopathic
Further Information
Publication History
Publication Date:
15 January 2004 (online)
ABSTRACT
Bronchiolitis is increasingly recognized as an important clinical syndrome that encompasses the broad spectrum of histopathologic processes which show some degree of inflammation, narrowing, or obliteration of the small conducting airways. It has an extremely variable clinical course, etiology, and histologic appearance. Understanding of this entity has been limited because until recently only case reports described this lesion in several diverse clinical settings. In addition, there has been considerable confusion as a result of the different terminologies applied to the many syndromes. This article reviews the clinical, radiographic, and histopathologic findings of the bronchiolar syndromes that are secondary to inhalation of chemicals or organic dust, that are secondary to infection, that are drug-induced, and that have no known etiology (idiopathic).
KEYWORDS
Bronchiolitis - inhalational injury - diffuse panbronchiolitis - volatile flavoring agents - bronchiolitis obliterans
REFERENCES
- 1 King Jr T E. Bronchiolitis. In: Schwarz MI, King TE, Jr, eds. Interstitial Lung Diseases. 4th ed. Hamilton, Ontario, Canada: BC Decker 2003
MissingFormLabel
- 2 Becklake M R, Goldman H I, Bosman A R, Freed C C. The long-term effects of exposure to nitrous fumes. Am Rev Tuberc . 1957; 76 398-409
- 3 Ramirez R J, Dowell A R. Silo-filler's disease: nitrogen dioxide-induced lung injury: long-term follow-up and review of the literature. Ann Intern Med . 1971; 74 569-576
- 4 Jones G R, Proudfoot A T, Hall J I. Pulmonary effects of acute exposure to nitrous fumes. Thorax . 1973; 28 61-65
- 5 Clutton-Brock J. Two cases of poisoning by contamination of nitrous oxide with higher oxides of nitrogen during anesthesia. Br J Anaesth . 1967; 39 388-392
- 6 Fleming G M, Chester E H, Montenegro H D. Dysfunction of small airways following pulmonary injury due to nitrogen dioxide. Chest . 1979; 75 720-721
- 7 Sobonya R. Fatal anhydrous ammonia inhalation. Hum Pathol . 1977; 8 293-299
- 8 Burns T R, Mace M L, Greenberg S D, Jachimczyk J A. Ultrastructure of acute ammonia toxicity in the human lung. Am J Forensic Med Pathol . 1985; 6 204-210
- 9 Koren H S, Devlin R B, Graham D E. et al . Ozone-induced inflammation in the lower airways of human subjects. Am Rev Respir Dis . 1989; 139 407-415
- 10 Graham D E, Koren H S. Biomarkers of inflammation of ozone-exposed humans: comparison of the nasal and bronchoalveolar lavage. Am Rev Respir Dis . 1990; 142 152-156
- 11 Paulo M, Gong H J. Respiratory effects of ozone: whom to protect, when, and how?. J Respir Dis . 1991; 12 482-499
- 12 Tyler W S, Julian M D, Hyde D M. Respiratory bronchiolitis following exposures to photochemical air pollutants. Sem Respir Med . 1992; 13 94-113
- 13 Wright J L. Inhalational lung injury causing bronchiolitis. Clin Chest Med . 1993; 14 635-644
- 14 Brooks S M, Weiss M A, Bernstein I L. Reactive airways dysfunction syndrome: persistent asthma syndrome after high irritant exposures. Chest . 1985; 88 376-384
- 15 Troisi F M. Delayed death caused by gassing in a silo containing green forage. Br J Ind Med . 1957; 14 56-58
- 16 Horvath E P, Colico D GA, Barbee R A, Dickie H A. Nitrogen dioxide-induced pulmonary disease. J Occ Med . 1978; 20 103-110
- 17 Milne J EH. Nitrogen dioxide inhalation and bronchiolitis obliterans. J Occup Med . 1969; 11 538-547
- 18 Yockey C C, Eden B M, Byrd R B. The McConnel missile accident: clinical spectrum of nitrogen dioxide exposure. JAMA . 1980; 244 1221-1223
- 19 Moskowitz R L, Lyons H A, Cottle H R. Silo-filler's disease: clinical, physiologic and pathologic study of patient. Am J Med . 1964; 36 457-462
- 20 Prowse K. Nitrous fume poisoning. Bull Europ Physiopath Resp . 1977; 13 191-202
- 21 Scott E U, Hunt W B. Silo-filler's disease. Chest . 1973; 63 701-706
- 22 Rafii S, Godwin M D. Relapse following latent period. Arch Path . 1961; 72 424-433
- 23 Douglas W W, Norman G, Hepper G, Colby T V. Silo-filler's disease. Mayo Clin Proc . 1989; 64 291-304
- 24 Woodford D M, Coutu R E, Gaensler E A. Obstructive lung disease from acute sulfur dioxide exposure. Respiration (Herrlisheim) . 1979; 38 238-245
- 25 Eichenberger A, Weber J, Hausser E. Pneumopathic des ensileus (silo-filler's disease). Schweiz Med Wschr . 1966; 96 1652-1655
- 26 Tse R L, Bockman A A. Nitrogen dioxide toxicity: report of four cases in firemen. JAMA . 1970; 212 1341-1344
- 27 Rigner K G, Swensson A. Late prognosis of nitrous fume poisoning and follow-up study. Acta Med Scand . 1961; 170 291-299
- 28 Kern D G, Crausman R S, Durand K T, Nayer A, Kuhn III C. Flock worker's lung: chronic interstitial lung disease in the nylon flocking industry. Ann Intern Med . 1998; 129 261-272
- 29 Kern D G, Kuhn III C, Ely E W. et al . Flock worker's lung: broadening the spectrum of clinicopathology, narrowing the spectrum of suspected etiologies. Chest . 2000; 117 251-259
- 30 Boag A H, Colby T V, Fraire A E. et al . The pathology of interstitial lung disease in nylon flock workers. Am J Surg Pathol . 1999; 23 1539-1545
- 31 Weiland D A, Lynch D A, Jensen S P. et al . Thin-section CT findings in flock worker's lung: a work-related interstitial lung disease. Radiology . 2003; 227 222-231
- 32 From the Centers for Disease Control and Prevention. Fixed obstructive lung disease in workers at a microwave popcorn factory-Missouri, 2000-2002. JAMA . 2002; 287 2939-2940
- 33 Fixed obstructive lung disease in workers at a microwave popcorn factory-Missouri, 2000-2002. MMWR Morb Mortal Wkly Rep . 2002; 51 345-347
- 34 Lockey J, McKay R, Barth E, Dahlsten J, Baughman R. Bronchiolitis obliterans in the food flavoring manufacturing industry. Am J Respir Crit Care Med . 2002; 165 A461
- 35 Kreiss K, Gomaa A, Kullman G. et al . Endemic bronchiolitis obliterans syndrome in microwave popcorn workers: a new occupational lung hazard. Am J Respir Crit Care Med . 2002; 165 A461
- 36 Kreiss K, Gomaa A, Kullman G, Fedan K, Simoes E J, Enright P L. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N Engl J Med . 2002; 347 330-338
- 37 Akpinar-Elci M, Kanwal R, Kreiss K. Bronchiolitis obliterans syndrome in popcorn plant workers. Am J Respir Crit Care Med . 2002; 165 A526
- 38 Lynch D A. Imaging of small airway disease. In: Kreiss K, ed. Bronchiolitis Obliterans in New Occupational Settings: Developing
a Clinical and Public Health Approach, August 25, 2001 Morgantown, WV: National Institute for Occupational Safety and Health (NIOSH) 2001
MissingFormLabel
- 39 Parmet A J, Von Essen S. Rapidly progressive, fixed airway obstructive disease in popcorn workers: a new occupational pulmonary illness?. J Occup Environ Med . 2002; 44 216-218
- 40 Schachter E N. Popcorn worker's lung. N Engl J Med . 2002; 347 360-361
- 41 Wohl M EB, Chernick V. Bronchiolitis: state of the art. Am Rev Respir Dis . 1978; 118 759-781
- 42 Smith C B, Overall C JJ. Clinical and epidemiologic clues to the diagnosis of respiratory infections. Radiol Clin North Am . 1973; 11 261-278
- 43 Penn C C, Liu C. Bronchiolitis following infection in adults and children. Clin Chest Med . 1993; 14 645-654
- 44 Wohl M EB. Bronchiolitis in children. In: Epler GR, ed. Diseases of the Bronchioles New York: Raven 1994: 397-407
MissingFormLabel
- 45 Hardy K A. Childhood bronchiolitis obliterans. In: Epler GR, ed. Diseases of the Bronchioles New York: Raven Press 1994: 415-426
MissingFormLabel
- 46 Coultas D B, Funk L M. Postinfectious bronchiolitis obliterans. In: Epler GR, ed. Diseases of the Bronchioles New York: Raven 1994: 215-229
MissingFormLabel
- 47 Ham J C. Acute infectious obstructing bronchiolitis: a potentially fatal disease in the adult. Ann Intern Med . 1964; 60 47-60
- 48 Harris C. Acute obstructive bronchiolitis: presentation of fatal case. JAMA . 1965; 194 203-205
- 49 Dines D E. Acute bronchiolitis as a cause of chronic obstructive lung disease in adults: report of two cases. Lancet . 1967; 87 281-282
- 50 Marinopoulos G C, Huddle K R, Wainwright H. Obliterative bronchiolitis: virus induced?. Chest . 1991; 99 243-245
- 51 Gosink B B, Friedman P J, Liebow A A. Bronchiolitis obliterans: roentgenologic-pathologic correlation. Am J Roentgenol Radium Ther Nucl Med . 1973; 117 816-832
- 52 Breatnach E, Kerr I. The radiology of cryptogenic obliterative bronchiolitis. Clin Radiol . 1982; 33 657-661
- 53 Green M. Bronchiolitis. In: Sadaul P, Milic-Emili J, Simonsson BG, Clark TJH, eds. Small Airways in Health
and Disease Amsterdam: Excerpta Medica (ICS 485) 1979: 90-94
MissingFormLabel
- 54 Wohl M E. Present capacity to evaluate pulmonary function relevant to bronchiolitis. Pediatr Res . 1977; 11(3 pt 2) 252-253
- 55 McLean K H. The pathology of acute bronchiolitis: a study of its evolution, II: The repair phase. Aust Ann Med . 1957; 6 29-43
- 56 McLean K H. The pathology of acute bronchiolitis: a study of its evolution, I: The exudative phase. Aust Ann Med . 1956; 5 254-267
- 57 Mauad T, Dolhnikoff M. Histology of childhood bronchiolitis obliterans. Pediatr Pulmonol . 2002; 33 466-474
- 58 Friis B, Andersen P, Brene E. et al . Antibiotic treatment of pneumonia and bronchiolitis: a prospective randomised study. Arch Dis Child . 1984; 59 1038-1045
- 59 Klassen T P, Rowe P C, Sutcliffe T, Ropp L J, Mcdowell I W, Li M M. Randomized trial of salbutamol in acute bronchiolitis. J Pediatr . 1991; 118 807-811
- 60 Caramia G, Palazzini E. Efficacy of ribavirin aerosol treatment for respiratory syncytial virus bronchiolitis in infants. J Int Med Res . 1987; 15 227-233
- 61 Hefelfinger D C. Bronchiolitis: a clearer picture is emerging. J Respir Dis . 1986; 7(11) 17-27
- 62 Mellins R B. Bronchiolitis: comments on pathogenesis and treatment. Pediatr Res . 1977; 11 268-269
- 63 Ellis E F. Therapy of acute bronchiolitis. Pediatr Res . 1977; 11 263-264
- 64 Hall W J, Hall C B. Clinical significance of pulmonary function tests: alterations in pulmonary function following respiratory vital infection. Chest . 1979; 76 458-465
- 65 McConnochie K M, Roghmann K J. Predicting clinically significant lower respiratory tract illness in childhood following mild bronchiolitis. Am J Dis Child . 1985; 139 625-631
- 66 McIntosh K. Bronchiolitis and asthma: possible common pathogenetic pathways. J Allergy Clin Immunol . 1976; 57 595-604
- 67 Twiggs J T, Larson L A, O'Connell E J, Ilstrup D M. Respiratory syncytial virus infection: ten-year follow-up. Clin Pediatr (Phila) . 1981; 20 187-190
- 68 Weiss S T, Tager I B, Munoz A, Speizer F E. The relationship of respiratory infections in early childhood to the occurrence of increased levels of bronchial responsiveness and atopy. Am Rev Respir Dis . 1985; 131 573-578
- 69 McConnochie K M, Mark J D, McBride J T. et al . Normal pulmonary function measurements and airway reactivity in childhood after mild bronchiolitis. J Pediatr . 1985; 107 54-58
- 70 Holness I, Tenebaum J, Cooter N B, Grossman R F. Fatal bronchiolitis obliterans associated with chrysotherapy. Ann Rheum Dis . 1983; 42 593-596
- 71 Turner-Warwick M. Adverse reactions affecting the lung: possible association with D-penicillamine. J Rheumatol . 1981; 7 166-168
- 72 Camus P. The respiratory complications of D-penicillamine therapy (author's translation). Rev Fr Mal Respir . 1982; 10 7-20
- 73 Yam L Y, Wong R. Bronchiolitis obliterans and rheumatoid arthritis: report of a case in a Chinese patient on D-penicillamine and review of the literature. Ann Acad Med Singapore . 1993; 22 365-368
- 74 Lin T J, Lu Lu C C, Chen K W, Deng J F. Outbreak of obstructive ventilatory impairment associated with consumption of Sauropus androgynus vegetable J Toxicol Clin Toxicol . 1996; 34 1-8
- 75 Lai R S, Chiang A A, Wu Wu T M. et al . Outbreak of bronchiolitis obliterans associated with consumption of Sauropus androgynus in Taiwan. Lancet . 1996; 348 83-85
- 76 Chen C W, Hsiue T R, Chen K W, Chang H Y, Chen C R, Yang B C. Increased IL-5 and IL-10 transcription in bronchial cells after Sauropus androgynus ingestion. J Formos Med Assoc . 1996; 95 699-702
- 77 Chang H, Wang J S, Tseng H H, Lai R S, Su J M. Histopathological study of Sauropus androgynus-associated constrictive bronchiolitis obliterans: a new cause of constrictive bronchiolitis obliterans. Am J Surg Pathol . 1997; 21 35-42
- 78 Yang C F, Wu M T, Chiang A A. et al . Correlation of high-resolution CT and pulmonary function in bronchiolitis obliterans: a study based on 24 patients associated with consumption of Sauropus androgynus Am J Roentgenol . 1997; 168 1045-1050
- 79 Wang J S, Tseng H H, Lai R S, Hsu H K, Ger L P. Sauropus androgynus-constrictive obliterative bronchitis/bronchiolitis-histopathological study of pneumonectomy and biopsy specimens with emphasis on the inflammatory process and disease progression. Histopathology . 2000; 37 402-410
- 80 Chang Y L, Yao Y T, Wang N S, Lee Y C. Segmental necrosis of small bronchi after prolonged intakes of Sauropus androgynus in Taiwan. Am J Respir Crit Care Med . 1998; 157 594-598
- 81 Turton C W, William G, Green M. Cryptogenic obliterative bronchiolitis in adults. Thorax . 1981; 36 805-810
- 82 Dorinsky P M, Davis W B, Lucas J G, Weiland J E, Gadek J E. Adult bronchiolitis: evaluation by bronchoalveolar lavage and response to prednisone therapy. Chest . 1985; 88 58-63
- 83 Kindt G C, Weiland J E, Davis W B, Gadek J E, Dorinsky P M. Bronchiolitis in adults: a reversible cause of airway obstruction associated with airway neutrophils and neutrophil products. Am Rev Respir Dis . 1989; 140 483-492
- 84 Meier-Sydow J, Schneider M, Rust M. Chronic bronchiolitis in adults. Eur J Respir Dis . 1986; 69(suppl. 146) 337-344
- 85 Kraft M, Mortenson R L, Colby T V, Newman L, Waldron Jr J, King Jr E T. Cryptogenic constrictive bronchiolitis. Am Rev Respir Dis . 1993; 148 1093-1101
- 86 Edwards C, Cayton R, Bryan R. Chronic transmural bronchiolitis: nonspecific lesion of small airways. J Clin Pathol . 1992; 45 993-998
- 87 Jensen S P, Lynch D A, Brown K K, Wenzel S E, Newell J D. High-resolution CT features of severe asthma and bronchiolitis obliterans. Clin Radiol . 2002; 57 1078-1085
- 88 Homma H, Yamanaka A, Tanimoto S. et al . Diffuse panbronchiolitis: a disease of the transsitional zone of the lung. Chest . 1983; 83 63-69
- 89 Izumi T. A nation-wide survey of diffuse panbronchiolitis in Japan. In: Grassi C, Rizzato G, Pozzi E, eds. Sarcoidosis and Other Granulomatous Disorders New York: Elsevier Science 1988: 753-757
MissingFormLabel
- 90 Sugiyama Y. Diffuse panbronchiolitis. Clin Chest Med . 1993; 14 765-772
- 91 Fisher Jr S M, Rush W L, Rosado-de-Christenson M L. et al . Diffuse panbronchiolitis: histologic diagnosis in unsuspected cases involving North American residents of Asian descent. Arch Pathol Lab Med . 1998; 122 156-160
- 92 Randhawa P, Hoagland M H, Yousem S A. Diffuse panbronchiolitis in North America: report of three cases and review of the literature. Am J Surg Pathol . 1991; 15 43-47
- 93 Poletti V, Patelli M, Poletti G, Bertanti T, Spiga L. Diffuse panbronchiolitis observed in an Italian (letter). Chest . 1990; 98 515-516
- 94 Homer R J, Khoo L, Smith G J. Diffuse panbronchiolitis in a Hispanic man with travel to Japan. Chest . 1995; 107 1176-1178
- 95 Fitzgerald J E, King Jr E T, Lynch D A, Tuder R M, Schwarz M I. Diffuse panbronchiolitis in the United States. Am J Respir Crit Care Med . 1996; 154 497-503
- 96 Martinez J A, Guimaraes S M, Ferreira R G, Pereira C A. Diffuse panbronchiolitis in Latin America. Am J Med Sci . 2000; 319 183-185
- 97 Souza R, Kairalla R A, Santos Ud Ude P, Takagaki T Y, Capelozzi V L, Carvalho C R. Diffuse panbronchiolitis: an underdiagnosed disease?. <~>Study of 4 cases in Brazil. Rev Hosp Clin Fac Med Sao Paulo . 2002; 57(4) 167-174
- 98 Sugiyama Y, Kudoh S, Maeda H, Suzaki H, Takaku F. Analysis of HLA antigens in patients with diffuse panbronchiolitis. Am Rev Respir Dis . 1990; 141 1459-1462
- 99 Yamanishi Y, Maeda H, Hiyama K, Ishioka S, Yamakido M. Rheumatoid arthritis associated with diffuse panbronchiolitis. Intern Med . 1998; 37 338-341
- 100 Ono K, Shimamoto Y, Matsuzaki M. et al . Diffuse panbronchiolitis as a pulmonary complication in patients with adult T-cell leukemia. Am J Hematol . 1989; 30 86-90
- 101 Koga T. Neutrophilia and high level of interleukin 8 in the bronchoalveolar lavage fluid of diffuse panbronchiolitis. Kurume Med J . 1993; 40 139-146
- 102 Kawakami K, Kadota J, Iida K. et al . Phenotypic characterization of T cells in bronchoalveolar lavage fluid (BALF) and peripheral blood of patients with diffuse panbronchiolitis; the importance of cytotoxic T cells. Clin Exp Immunol . 1997; 107 410-416
- 103 Nakano H, Ide H, Imada M. et al . Reduced nasal nitric oxide in diffuse panbronchiolitis. Am J Respir Crit Care Med . 2000; 162 2218-2220
- 104 Sueyasu Y. Diffuse panbronchiolitis: a thin-section CT scoring system. Kurume Med J . 1996; 43 63-71
- 105 Iwata M, Colby T V, Kitaichi M. Diffuse panbronchiolitis: diagnosis and distinction from various pulmonary diseases with centrilobular interstitial foam cell accumulations. Hum Pathol . 1994; 25 357-363
- 106 Baz M A, Kussin P S, Trigt P V, Davis R D, Roggli V L, Tapson V F. Recurrence of diffuse panbronchiolitis after lung transplantation. Am J Respir Crit Care Med . 1995; 151 895-898
- 107 Goldstein B G, Goldstein A O. Pemphigus and bullous pemphigoid. In: Rose BD, ed. UpToDate Wellesley, MA: UpToDate 2002
MissingFormLabel
- 108 Anhalt G J, Kim S C, Stanley J R. et al . Paraneoplastic pemphigus: an autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med . 1990; 323 1729-1735
- 109 Kimyai-Asadi A, Jih M H. Paraneoplastic pemphigus. Int J Dermatol . 2001; 40 367-372
- 110 Nousari H C, Deterding R, Wojtczack H. et al . The mechanism of respiratory involvement in paraneoplastic pemphigus. N Engl J Med . 1999; 340 1406-1410
- 111 Fullerton S H, Woodley D T, Smoller B R, Anhalt G J. Paraneoplastic pemphigus with autoantibody deposition in bronchial epithelium after autologous bone marrow transplantation. JAMA . 1992; 267 1500-1502
- 112 Saito K, Morita M, Enomoto K. Bronchiolitis obliterans with pemphigus vulgaris and Castleman's disease of hyaline-vascular type: an autopsy case analyzed by computer-aided 3-D reconstruction of the airway lesions. Hum Pathol . 1997; 28 1310-1312
- 113 Kim S C, Chang S N, Lee I J. et al . Localized mucosal involvement and severe pulmonary involvement in a young patient with paraneoplastic pemphigus associated with Castleman's tumour. Br J Dermatol . 1998; 138 667-671
- 114 Chorzelski T, Hashimoto T, Maciejewska B, Amagai M, Anhalt G, Jablonska S. Paraneoplastic pemphigus associated with Castleman tumor, myasthenia gravis and bronchiolitis obliterans. J Am Acad Dermatol . 1999; 41 393-400
- 115 Hasegawa Y, Shimokata K, Ichiyama S, Saito H. Constrictive bronchiolitis obliterans and paraneoplastic pemphigus. Eur Respir J . 1999; 13 934-937
- 116 Wolff H, Kunte C, Messer G. et al . Paraneoplastic pemphigus with fatal pulmonary involvement in a woman with a mesenteric Castleman tumour. Br J Dermatol . 1999; 140 313-316
- 117 Takahashi M, Shimatsu Y, Kazama T, Kimura K, Otsuka T, Hashimoto T. Paraneoplastic pemphigus associated with bronchiolitis obliterans. Chest . 2000; 117 603-607
- 118 van der Waal I R, Pas H H, Nousari H C. et al . Paraneoplastic pemphigus caused by an epithelioid leiomyosarcoma and associated with fatal respiratory failure. Oral Oncol . 2000; 36 390-393
- 119 Chin A C, Stich D, White F V, Radhakrishnan J, Holterman M J. Paraneoplastic pemphigus and bronchiolitis obliterans associated with a mediastinal mass: a rare case of Castleman's disease with respiratory failure requiring lung transplantation. J Pediatr Surg . 2001; 36 E22
- 120 Cordel N, Ringeisen F, Antoine M, Cadranel J, Aractingi S. Paraneoplastic pemphigus with constrictive bronchiolitis obliterans. Dermatology . 2001; 202 145
- 121 Fujimoto W, Kanehiro A, Kuwamoto-Hara K. et al . Paraneoplastic pemphigus associated with Castleman's disease and asymptomatic bronchiolitis obliterans. Eur J Dermatol . 2002; 12 355-359
- 122 Osmanski II P J, Fraire A E, Schaefer O P. Necrotizing tracheobronchitis with progressive airflow obstruction associated with paraneoplastic pemphigus. Chest . 1997; 112 1704-1707