Planta Med 2004; 70(3): 234-238
DOI: 10.1055/s-2004-815540
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

New Lignans and Cytotoxic Constituents from Wikstroemia lanceolata

Ru-Wei Lin1 , Ian-Lih Tsai1 , Chang-Yih Duh2 , Kuo-Hsiung Lee3 , Ih-Sheng Chen1
  • 1Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
  • 2Graduate Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China
  • 3Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, U.S.A.
This research was financially supported by the National Science Council of the Republic of China
Weitere Informationen

Publikationsverlauf

Received: July 10, 2003

Accepted: November 22, 2003

Publikationsdatum:
23. März 2004 (online)

Preview

Abstract

Two new lignans, (-)-aptosimon (1) and (-)-diasesamin-di-γ-lactone (2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known sesquiterpenoid, 1α,7α,10αH-guaia-4,11-dien-3-one (24) were revised by 2D NMR techniques. Among the isolates, three compounds, (+)-hinokinin (6), 2,6-dimethoxy-p-benzoquinone (17), and 1α,7α,10αH-guaia-4,11-dien-3-one (24) exhibited effective cytotoxicities (ED50 values < 4.0 μg mL-1) against P-388 and HT-29 tumor cell lines.

References

Prof. Dr. I. S. Chen

Graduate Institute of Natural Products

Kaohsiung Medical University

Kaohsiung

Taiwan 807

Republic of China

Telefon: +886-7-3121101 ext 2123

Fax: +886-7-3210683

eMail: m635013@kmu.edu.tw