Planta Med 2004; 70(1): 54-58
DOI: 10.1055/s-2004-815456
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

New Diarylheptanoids from the Rhizomes of Dioscorea spongiosa and Their Antiosteoporotic Activity

Jun Yin1 , Kyoji Kouda1 , Yasuhiro Tezuka1 , Quan Le Tran1 , Tatsuro Miyahara2 , Yingjie Chen3 , Shigetoshi Kadota1
  • 1Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
  • 2Faculty of Pharmaceutical Science, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
  • 3Shenyang Pharmaceutical University, 105 Wenhua Road, Shenyang, P.R. China
Further Information

Publication History

Received: June 16, 2003

Accepted: October 3, 2003

Publication Date:
06 February 2004 (online)

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Abstract

Bioassay-guided fractionation of the water extract of the rhizomes of Dioscorea spongiosa led to the isolation and identification of new diarylheptanoids, diospongins A - C, together with three known lignans. Their structures, including absolute stereochemistry, were determined by analyses of NMR data, chemical conversions and CD spectrum. The isolated compounds, except for diospongin A, exerted potent inhibitory activities on bone resorption induced by parathyroid hormone in a bone organ culture system.

References

Prof. Dr. Shigetoshi Kadota

Department of Natural Products Chemistry

Institute of Natural Medicine

Toyama Medical and Pharmaceutical University

2630 Sugitani

Toyama 930-0194

Japan

Phone: +81-76-434-7625

Fax: +81-76-434-5059

Email: kadota@ms.toyama-mpu.ac.jp