The Effect of Gender and Age on Growth Hormone Replacement in Growth Hormone-Deficient Patients

E. Hubina; L. Kovács; I. Szabolcs; N. Szücs; M. Tóth; K. Rácz; S. Czirják; Z. Görömbey; M. I. Góth

doi:10.1055/s-2004-814458

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2004; 36(4): 247-253
DOI: 10.1055/s-2004-814458

Original Clinical

The Effect of Gender and Age on Growth Hormone Replacement in Growth Hormone-Deficient Patients

E. Hubina¹ , L. Kovács¹ , I. Szabolcs¹ , N. Szücs² , M. Tóth² , K. Rácz² , S. Czirják³ , Z. Görömbey¹ , M. I. Góth¹

¹Department of Medicine, National Medical Centre
²2^nd Department of Medicine, Faculty of Medicine, Semmelweis University
³National Institute of Neurosurgery, Budapest, Hungary

Abstract

We analyzed the effect of growth hormone replacement therapy (36 months) analyzed at a dose adjusted to maintain serum insulin-like growth factor-I level between the median and the upper end of the age-related reference range on bone mineral density, body composition, and carbohydrate metabolism with respect to gender and age in 20 adult patients (9 women, 11 men, mean age: 43 years, range: 21-61 years). The lumbar and femoral T-score was increased after 12 and after 18 months of therapy respectively in men (p < 0.001 and p = 0.002), but did not changed significantly in women. The increase of femoral T-score was greater in young men (≤ 45 years, n = 6) than old men (> 45 years, n = 5, p < 0.001). Body fat was lower in men than in women after 6 months (p = 0.002). The waist/hip ratio only decreased in women (p = 0.044). The waist circumference decreased in both genders after 6 months of therapy (p < 0.001), but more markedly in females than in males (p < 0.05). The sum of skinfold thicknesses was reduced in males after 6 months of therapy (p < 0.001). Changes in body composition parameters measured were independent of age. The glycosylated hemoglobin increased without sex or age difference after 12 months of initiation of therapy (p < 0.001), but fasting glucose and insulin levels did not change during the therapy. Our results indicate that the effect of growth hormone replacement on bone mineral content in adults is age- and gender-dependent, gender dependent on body composition, but independent of age and gender on carbohydrate metabolism.

Key words

Growth hormone replacement - Gender difference - Age difference - Bone density - Body composition - Carbohydrate metabolism

Full Text

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M. I. Góth

Department of Medicine · National Medical Center

1389 Budapest · P.O. Box 112 · Hungary ·

Phone: +36(1)3594264

Fax: +36(1)3594264

Email: goth@hiete.hu