Signal Transducing Kinases and Cancer

Abstract

Protein kinases are critical components within signal transduction pathways responsible for cellular development, growth, communication and cell death. They gained special interest among clinicians since several types of cancer and other disorders are associated with deregulated tyrosine kinase signalling. Recently a number of kinase inhibitors became available for clinical use and new challenges are to find out which patients are most likely to respond to these inhibitors. Additionally, new clinical trials are needed to unravel the full potential of all these inhibitors. Therefore, this article tries to summarize some mechanistical aspects of tyrosine kinase signalling which may be a target for cancer therapy.

Key words

Receptor tyrosine Kinases - imatinib kit - mutations

References

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