Aktuelle Neurologie 2004; 31(4): 180-187
DOI: 10.1055/s-2003-814931
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Spontane Kleinhirnblutung

Wann ist eine chirurgische Therapie indiziert?Spontaneous Cerebellar HemorrhageIndications for Surgical TreatmentS.  Schwarz1 , M.  Daffertshofer1 , S.  Dolderer2 , D.  Georgiadis3 , A.  Aschoff4
  • 1Neurologische Universitätsklinik, Klinikum Mannheim der Universität Heidelberg
  • 2Neurologische Klinik, Universität Heidelberg
  • 3Neurologische Klinik, Universitätsspital Zürich, Schweiz
  • 4Neurochirurgische Klinik, Universität Heidelberg
Further Information

Publication History

Publication Date:
07 May 2004 (online)

Zusammenfassung

Konservative Therapieverfahren wurden bisher bei der Kleinhirnblutung nicht untersucht. Vielfach wird eine operative Hämatomausräumung bei Patienten mit großen Hämatomen, Hydrozephalus oder Bewusstseinstrübung empfohlen. Die Detailindikation zur Operation wird allerdings sehr unterschiedlich gesehen. Kontrollierte Studien zur Hämatomausräumung bei Kleinhirnblutungen liegen nicht vor. Auch über das optimale chirurgische Verfahren besteht keine Einigkeit. Es werden verschiedene chirurgische Methoden der Hämatomausräumung mit oder ohne Anlage einer Ventrikeldrainage angewendet, ohne dass wissenschaftliche Daten für das jeweilige Verfahren sprechen. Die Langzeitprognose der Kleinhirnblutung ist unklar. Die bisherigen Studien zeigen sowohl unter konservativer und operativer Behandlung eine hohe Mortalität. Die operative Hämatomausräumung bei bestimmten Patienten hat sich heute weitgehend durchgesetzt. Aufgrund der dürftigen Datenlage ist der Nutzen dieser Behandlung aber nicht sicher geklärt.

Abstract

Up to now, specific medical treatment strategies for cerebellar hemorrhage are not established. Usually, surgical hematoma evacuation is recommended in patients with a large hematoma, hydrocephalus or loss of consciousness. However, the indications for surgical interventions are still controversial. Prospective studies on hematoma evacuation in patients with a cerebellar hemorrhage are not available. Furthermore, the optimum surgical treatment strategy remains debatable. The choice of surgical procedure remains highly controversial. Different surgical methods of hematoma evacuation with or without external ventricular drainage are employed. The long-term prognosis after cerebellar hemorrhage has not yet been satisfactorily evaluated. The mortality after surgical or medical treatment is still high. Therefore, although the surgical treatment is firmly established in the current clinical practice, the possible benefits of surgical hematoma evacuations are not proven, and new prospective studies are urgently warranted.

Literatur

  • 1 Brown-Sequard C E. Diagnosis of hemorrhage in the cerebellum.  Lancet. 1861;  2 391
  • 2 Tatu L, Moulin T, El Mohamad R. et al . Primary intracerebral hemorrhages in the Besancon stroke registry. Initial clinical and CT findings, early course and 30-day outcome in 350 patients.  Eur Neurol. 2000;  43 209-214
  • 3 Kobayashi S, Sato A, Kageyama Y. et al . Treatment of hypertensive cerebellar hemorrhage - surgical or conservative management?.  Neurosurgery. 1994;  34 246-250
  • 4 Dunne J W, Chakera T, Kermode S. Cerebellar haemorrhage - diagnosis and treatment: a study of 75 consecutive cases.  Q J Med. 1987;  64 739-754
  • 5 Dinsdale H B. Spontaneous hemorrhage in the posterior fossa.  Arch Neurol. 1964;  10 200-217
  • 6 Fisher C M, Picard E H, Polak A. et al . Acute hypertensive cerebellar hemorrhage: Diagnosis and surgical treatment.  J Nerv Ment Dis. 1965;  140 38-57
  • 7 Kase C S. Cerebellar Hemorrhage. In: Kase CS, Caplan LR (eds) Intracerebral Hemorrhage. Boston, London, Oxford; Butterworth-Heinemann 1994: 425-443
  • 8 Salvati M, Cervoni L, Raco A, Delfini R. Spontaneous cerebellar hemorrhage: clinical remarks on 50 cases.  Surg Neurol. 2001;  55 156-161
  • 9 Wanebo J E, Lonser R R, Glenn G M, Oldfield E H. The natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau disease.  J Neurosurg. 2003;  98 82-94
  • 10 Cuny E, Loiseau H, Rivel J. et al . Amyloid angiopathy-related cerebellar hemorrhage.  Surg Neurol. 1996;  46 235-239
  • 11 Itoh Y, Yamada M, Hayakawa M. et al . Cerebral amyloid angiopathy: a significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly.  J Neurol Sci. 1993;  116 135-141
  • 12 Hillairet J B. De l'haemorraghie cerebelleuse.  Arch Gen Med. 1858;  1 149-169
  • 13 Massie J D, Haussen S, Gerald B. Angiography of cerebellar hemorrhage secondary to hypertension.  Am J Roentgenol Radium Ther Nucl Med. 1975;  123 22-26
  • 14 Ott K H, Kase C S, Ojemann R G, Mohr J P. Cerebellar hemorrhage: diagnosis and treatment. A review of 56 cases.  Arch Neurol. 1974;  31 160-167
  • 15 Ballance H. A case of traumatic haemorrhage into the left lateral lobe of the cerebellum treated by operation with recovery.  Surg Gyn Obstet. 1906;  3 223-235
  • 16 Prasad K, Shrivastava A. Surgery for primary supratentorial intracerebral haemorrhage. Cochrane Database Syst Rev 2000, CD000200
  • 17 Broderick J P, Adams H P, Barsan W. et al . Guidelines for the management of spontaneous intracerebral hemorrhage: A statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association.  Stroke. 1999;  30 905-915
  • 18 Qureshi A I, Tuhrim S, Broderick J P. et al . Spontaneous intracerebral hemorrhage.  N Engl J Med. 2001;  344 1450-1460
  • 19 Poungvarin N, Bhoopat W, Viriyavejakul A. et al . Effects of dexamethasone in primary supratentorial intracerebral hemorrhage.  N Engl J Med. 1987;  316 1229-1233
  • 20 Tellez H, Bauer R B. Dexamethasone as treatment in cerebrovascular disease. 1. A controlled study in intracerebral hemorrhage.  Stroke. 1973;  4 541-546
  • 21 Bereczki D, Liu M, Prado G F do, Fekete I. Mannitol for acute stroke. Cochrane Database Syst Rev 2001, CD001153
  • 22 Candelise L, Colombo A, Spinnler H. Therapy against brain swelling in stroke patients. A retrospective clinical study on 227 patients.  Stroke. 1975;  6 353-356
  • 23 Nau R. Osmotherapy for elevated intracranial pressure: a critical reappraisal.  Clin Pharmacokinet. 2000;  38 23-40
  • 24 Cruz J, Minoja G, Okuchi K. Improving clinical outcomes from acute subdural hematomas with the emergency preoperative administration of high doses of mannitol: a randomized trial.  Neurosurgery. 2001;  49 864-871
  • 25 Gilliard C, Mathurin P, Passagia J G. et al . L'hématome sponatané du cervelet.  Neurochirurgie. 1990;  36 347-353
  • 26 Donauer E, Loew F, Faubert C. et al . Prognostic factors in the treatment of cerebellar haemorrhage.  Acta Neurochir (Wien). 1994;  131 59-66
  • 27 Wijdicks E F, St Louis E K, Atkinson J D, Li H. Clinician's biases toward surgery in cerebellar hematomas: an analysis of decision-making in 94 patients.  Cerebrovasc Dis. 2000;  10 93-96
  • 28 Wessels P H, Berg J W ter, Spincemaille G H, Dippel D W. Treatment of cerebellar hematoma in The Netherlands. A questionnaire survey.  Cerebrovasc Dis. 2001;  11 190-194
  • 29 Auer L M, Auer T, Sayama I. Indications for surgical treatment of cerebellar haemorrhage and infarction.  Acta Neurochir (Wien). 1986;  79 74-79
  • 30 Cohen Z R, Ram Z, Knoller N. et al . Management and outcome of non-traumatic cerebellar haemorrhage.  Cerebrovasc Dis. 2002;  14 207-213
  • 31 Kirollos R W, Tyagi A K, Ross S A. et al . Management of spontaneous cerebellar hematomas: a prospective treatment protocol.  Neurosurgery. 2001;  49 1378-1386
  • 32 St Louis E K, Wijdicks E F, Li H. Predicting neurologic deterioration in patients with cerebellar hematomas.  Neurology. 1998;  51 1364-1369
  • 33 Heiman T D, Satya-Murti S. Benign cerebellar hemorrhages.  Ann Neurol. 1978;  3 366-368
  • 34 Melamed N, Satya-Murti S. Cerebellar hemorrhage. A review and reappraisal of benign cases.  Arch Neurol. 1984;  41 425-428
  • 35 Greenberg J, Skubick D, Shenkin H. Acute hydrocephalus in cerebellar infarct and hemorrhage.  Neurology. 1979;  29 409-413
  • 36 Wijdicks E F. Recurrent cerebellar hematomas.  Stroke. 1995;  26 2198
  • 37 Shenkin H A, Zavala M. Cerebellar strokes: mortality, surgical indications, and results of ventricular drainage.  Lancet. 1982;  2 429-432
  • 38 Mezzadri J J, Otero J M, Ottino C A. Management of 50 spontaneous cerebellar haemorrhages. Importance of obstructive hydrocephalus.  Acta Neurochir (Wien). 1993;  122 39-44
  • 39 Little J R, Tubman D E, Ethier R. Cerebellar hemorrhage in adults. Diagnosis by computerized tomography.  J Neurosurg. 1978;  48 575-579
  • 40 Siddique M S, Mendelow A D. Surgical treatment of intracerebral haemorrhage.  Br Med Bull. 2000;  56 444-456
  • 41 Zieger A, Vonofakos D, Steudel W I, Dusterbehn G. Nontraumatic intracerebellar hematomas: prognostic value of volumetric evaluation by computed tomography.  Surg Neurol. 1984;  22 491-494
  • 42 Kothari R U, Brott T, Broderick J P. et al . The ABCs of measuring intracerebral hemorrhage volumes.  Stroke. 1996;  27 1304-1305
  • 43 Taneda M, Hayakawa T, Mogami H. Primary cerebellar hemorrhage. Quadrigeminal cistern obliteration on CT scans as a predictor of outcome.  J Neurosurg. 1987;  67 545-552
  • 44 Loon J van, Calenbergh F van, Goffin J, Plets C. Controversies in the management of spontaneous cerebellar haemorrhage. A consecutive series of 49 cases and review of the literature.  Acta Neurochir (Wien). 1993;  122 187-193
  • 45 Chin D, Carney P. Acute cerebellar hemorrhage with brainstem compression in contrast with benign cerebellar hemorrhage.  Surg Neurol. 1983;  19 406-409
  • 46 McKissock W. Spontaneous cerebellar haemorrhage. A study of 34 consecutive cases treated surgically.  Brain. 1960;  83 1-9
  • 47 Mathew P, Teasdale G, Bannan A, Oluoch-Olunya D. Neurosurgical management of cerebellar haematoma and infarct.  J Neurol Neurosurg Psychiatry. 1995;  59 287-292
  • 48 Lui T N, Fairholm D J, Shu T F. et al . Surgical treatment of spontaneous cerebellar hemorrhage.  Surg Neurol. 1985;  23 555-558
  • 49 Backlund E O, Holst H von. Controlled subtotal evacuation of intracerebral haematomas by stereotactic technique.  Surg Neurol. 1978;  9 99-101
  • 50 Niizuma H, Suzuki J. Computed tomography-guided stereotactic aspiration of posterior fossa hematomas: a supine lateral retromastoid approach.  Neurosurgery. 1987;  21 422-427
  • 51 Etou A, Mohadjer M, Braus D, Mundinger F. Stereotactic evacuation and fibrinolysis of cerebellar hematomas.  Stereotact Funct Neurosurg. 1990;  54 - 55 445-450
  • 52 Mohadjer M, Eggert R, May J, Mayfrank L. CT-guided stereotactic fibrinolysis of spontaneous and hypertensive cerebellar hemorrhage: long-term results.  J Neurosurg. 1990;  73 217-222
  • 53 Seelig J M, Selhorst J B, Young H F, Lipper M. Ventriculostomy for hydrocephalus in cerebellar hemorrhage.  Neurology. 1981;  31 1537-1540
  • 54 Firsching R, Huber M, Frowein R A. Cerebellar haemorrhage: management and prognosis.  Neurosurg Rev. 1991;  14 191-194
  • 55 Rousseaux M, Lesoin F, Combelle G. et al . Intérêt et limites de la dérivation ventriculaire isoleé dans les hématomes cérébelleux non traumatiques.  Neurochirurgie. 1984;  30 41-44
  • 56 Nieuwkamp D J, Gans K de, Rinkel G J, Algra A. Treatment and outcome of severe intraventricular extension in patients with subarachnoid or intracerebral hemorrhage: a systematic review of the literature.  J Neurol. 2000;  247 117-121
  • 57 Schwarz S, Schwab S, Steiner H H. et al . Fibrinolyse intraventrikulärer Hämatome mit rt-PA.  Nervenarzt. 1999;  70 123-130
  • 58 Cuneo R A, Caronna J J, Pitts L. et al . Upward transtentorial herniation: seven cases and a literature review.  Arch Neurol. 1979;  36 618-623
  • 59 Waidhauser E, Hamburger C, Marguth F. Neurosurgical management of cerebellar hemorrhage.  Neurosurg Rev. 1990;  13 211-217
  • 60 Hoop R G van der, Vermeulen M, Gijn J van. Cerebellar hemorrhage: diagnosis and treatment.  Surg Neurol. 1988;  29 6-10
  • 61 Rothwell P M, Slattery J, Warlow C P. A systematic review of the risks of stroke and death due to endarterectomy for symptomatic carotid stenosis.  Stroke. 1996;  27 260-265
  • 62 Buchanan K M, Elias L J, Goplen G B. Differing perspectives on outcome after subarachnoid hemorrhage: the patient, the relative, the neurosurgeon.  Neurosurgery. 2000;  46 831-838
  • 63 Luparello V, Canavero S. Treatment of hypertensive cerebellar hemorrhage - surgical or conservative management?.  Neurosurgery. 1995;  37 552-553
  • 64 Kelly P J, Stein J, Shafqat S. et al . Functional recovery after rehabilitation for cerebellar stroke.  Stroke. 2001;  32 530-534
  • 65 Counsell C, Boonyakarnkul S, Dennis M. et al . Primary intracerebral haemorrhage in the Oxfordshire community stroke project, 2: prognosis.  Cerebrovasc Dis. 1995;  5 26-34
  • 66 Brennan R W, Bergland R M. Acute cerebellar hemorrhage. Analysis of clinical findings and outcome in 12 cases.  Neurology. 1977;  27 527-532
  • 67 Rosenberg G A, Kaufman D M. Cerebellar hemorrhage: reliability of clinical evaluation.  Stroke. 1976;  7 332-336
  • 68 Sypert G WA, Lvord E C. Cerebellar infarction. A clinicopathological study.  Arch Neurol. 1975;  32 357-363
  • 69 Bogousslavsky J, Regli F, Jeanrenaud X. Benign outcome in unoperated large cerebellar haemorrhage. Report of 2 cases.  Acta Neurochir (Wien). 1984;  73 59-65
  • 70 Norris J W, Eisen A A, Branch C L. Problems in cerebellar hemorrhage and infarction.  Neurology. 1969;  19 1043-1050
  • 71 Yoshida S, Sasaki M, Oka H. et al . Acute hypertensive cerebellar hemorrhage with signs of lower brainstem compression.  Surg Neurol. 1978;  10 79-83
  • 72 Pian R Da, Bazzan A, Pasqualin A. Surgical versus medical treatment of spontaneous posterior fossa haematomas: a cooperative study on 205 cases.  Neurol Res. 1984;  6 145-151
  • 73 Koziarski A, Frankiewicz E. Medical and surgical treatment of intracerebellar haematomas.  Acta Neurochir (Wien). 1991;  110 24-28

PD Dr. Stefan Schwarz

Neurologische Universitätsklinik · Klinikum Mannheim der Universität Heidelberg

Theodor-Kutzer-Ufer 1 - 3

68135 Mannheim

Email: s.schwarz@neuro.ma.uni-heidelberg.de

    >