End-Tidal CO2 as a Function of Tidal Volume in Mechanically Ventilated Infants

Karen J. Greer; Winslade A. Bowen; Alfred N. Krauss

doi:10.1055/s-2003-45390

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2003; 20(8): 447-452
DOI: 10.1055/s-2003-45390

ORIGINAL ARTICLE

End-Tidal CO₂ as a Function of Tidal Volume in Mechanically Ventilated Infants

Karen J. Greer, Winslade A. Bowen, Alfred N. Krauss

Perinatology Center, Department of Pediatrics, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York

Abstract

ABSTRACT

Objective: To test the hypothesis that end-tidal CO₂ (PETCO₂) varies with tidal volume (Vt) in preterm infants. Design: Intervention study, nonrandomized trial. Setting: Neonatal ICU, regional referral center. Subjects: 29 preterm infants 790 to 2135 g in weight requiring mechanical ventilation studied on 73 occasions. Intervention: Measurement of PETCO₂ during variations of Vt. Measurement: Statistical correlation of PETCO₂ to Vt. Result: PETCO₂ is minimal when Vt is either too low or too high. Conclusion: Vt, through its effect on dead space/Vt (Vd/Vt) ratios and arterial-alveolar CO₂ differences, has a significant effect on PETCO₂. Observation of PETCO₂ across a range of Vt can be used to select an appropriate Vt for preterm infants requiring mechanical ventilation.

KEYWORDS

Mechanical ventilation - preterm infants - end-tidal CO₂

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Referenzen

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