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Am J Perinatol 2003; 20(5): 269-272
DOI: 10.1055/s-2003-42337
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Disseminated Trichosporon asahii Infection in a Preterm

Alişan Yıldıran1 , Şükrü Kücüködük1 , Ahmet Saniç2 , Nurşen Belet1 , Abdullah Güvenli2
  • 1Department of Pediatrics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
  • 2Department of Microbiology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
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Publication History

Publication Date:
18 September 2003 (online)

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ABSTRACT

Trichosporon asahii (T. asahii) is an uncommon cause of yeast infection in preterms. We present a 27-week gestational age female with clinical evidence of sepsis, such as patchy infiltrations on chest roentgenogram, and yeast growing in urine and blood cultures. Conventional amphotericin B was empirically added in a dose of 0.5 mg/kg, q8h to standard protocol of the neonatal intensive care unit. Dose of the drug was induced to 1 mg/kg because the patient had not improved when the organism was identified as T. asahii on the pretreatment urine and blood cultures. Both cultures were clear on the 10th day of amphotericin B therapy and treatment was ceased on the 21st day. The patient was healthy when discharged. Trichosporon infections in neonates have been almost uniformly fatal. Most strains of T. asahii may be confused with Candida spp. on initial culture examinations. Therefore, delays in appropriate treatment may occur.

KEYWORDS

Trichosporon asahii, preterm - amphotericin B

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