Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000048.xml
Osteosynthesis and Trauma Care 2003; 11(1): 38-40
DOI: 10.1055/s-2003-40119
DOI: 10.1055/s-2003-40119
Case Report
© Georg Thieme Verlag Stuttgart · New York
Neutropenia Associated with Piperacillin/Tazobactam (Zosyn) in the Treatment of Orthopedic Injuries: A Case Report
Further Information
Publication History
Publication Date:
20 June 2003 (online)
Abstract
Neutropenia is a potentially fatal complication of intravenous Piperacillin/Tazobactam therapy not previously reported in the orthopedic literature. We report five cases that presented to the orthopedic service in a two-month period.
Key words
Neutropenia - Piperacillin/Tazobactam - Orthopedics - Open Fractures
References
- 1 Lang R, Lishner M, Ravid M. Adverse reactions to prolonged treatment with high doses of carbenicillin and ureidopenicillins. Rev Infect Dis. 1991; 13 68-72
- 2 Gerber L, Wing E J. Life-threatening neutropenia secondary to piperacillin/tazobactam therapy. Clin Infect Dis. 1995; 21 1047-1048
- 3 Mallon P, Murphy P, Elborn S. Fever associated with intravenous antibiotics in adults with cystic fibrosis. Lancet. 1997; 350 1676-1677
- 4 Reichardt P, Handrick W, Linke A, Schille R, Kiess W. Leukocytopenia, thrombocytopenia and fever related to piperacillin/tazobactam treatment - a retrospective analysis in 38 children with cystic fibrosis. Infection. 1999; 27 355-356
- 5 Toyonaga Y, Ishihara T, Tezuka T, Nakamura H. [Pharmacokinetic and clinical evaluation of tazobactam/piperacillin in the pediatric field]. Jpn J Antibiot. 1998; 51 325-345
- 6 Patzakis M J, Wilkins J. Factors influencing infection rate in open fracture wounds. Clin Orthop. 1989; 36-40
- 7 Wilkins J, Patzakis M. Choice and duration of antibiotics in open fractures. Orthop Clin North Am. 1991; 22 433-437
- 8 Archer G, Polk R. Treatment and prophylaxis of bacterial infections. In al. FAe (ed): Harrison’s Principles of Internal Medicine (ed 14), McGraw-Hill 1998; pp 856-868
- 9 Muller T HT. Efficacy and safety of Tazobactam/Piperacillin in the treatment of bone and joint infections. Paper presented at the The 4th Biennial Conference on Chemotherapy of Infectious Diseases and Malignancies, Czechoslovakia 1992
- 10 Incavo S J. Penetration of piperacillin-tazobactam into cancellous and cortical bone tissues. Antimicrobial Agents & Chemotherapy. 1994; 38 905-907
Gary S. Gruen MD
Department of Orthopedic Surgery · University of Pittsburgh Medical Center
3471 Fifth Avenue, Suite 1010
Pittsburgh, PA 15213
USA
Phone: +1/4 12/6 05 32 11
Fax: +1/4 12/6 87 37 24
Email: ggruen@uoi.upmc.edu