Planta Med 2003; 69(5): 440-444
DOI: 10.1055/s-2003-39711
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

New Cytotoxic Oleanane Saponins from the Infructescences of Polyscias amplifolia from the Madagascar Rainforest

V. S. Prakash Chaturvedula1 , Jennifer K. Schilling1 , James S. Miller2 , Rabodo Andriantsiferana3 , Vincent E. Rasamison3 , David G. I. Kingston1
  • 1Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
  • 2Missouri Botanical Garden, St. Louis, Missouri, USA
  • 3Centre National d'Application et des Recherches Pharmaceutiques, Antananarivo, Madagascar
Further Information

Publication History

Received: September 12, 2002

Accepted: January 25, 2003

Publication Date:
12 June 2003 (online)

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Abstract

Bioassay-guided fractionation of an ethanolic extract of the infructescences of Polyscias amplifolia resulted in the isolation of two new oleanolic acid saponins, polyfoliolides A (1) and B (2), in addition to the two known saponins 3-O-β-D-galactopyranosyloleanolic acid (3) and 3-O-β-D-galactopyranosyl-(1→4)-β-D-galactopyranosyloleanolic acid (4). The structures of the two new compounds were established as 3-O-β-D-galactopyranosyl-(1→4)-β-D-xylopyranosyloleanolic acid (1) and 3-O-β-D-galactopyranosyl-(1→4)-α-L-arabinopyranosyloleanolic acid (2) on the basis of extensive 1D and 2D NMR spectroscopic data interpretation and chemical conversions. All the isolated compounds showed weak cytotoxicity against A2780 human ovarian cancer cell line, with IC50 values in the range 6.7 to 10.8 μg/mL.

References

Dr. David G. I. Kingston

Department of Chemistry

M/C 0212

Virginia Polytechnic Institute and State University

Blacksburg

VA 24061

USA

Phone: +1-540-231-6570

Fax: +1-540-231-7702

Email: dkingston@vt.edu