Planta Med 2003; 69(5): 462-464
DOI: 10.1055/s-2003-39703
Letter
© Georg Thieme Verlag Stuttgart · New York

New Cytotoxic Sesquiterpene Lactones from Warionia saharae

Fatima Hilmi1 , Otto Sticher1 , Jörg Heilmann1
  • 1Department of Chemistry and Applied BioSciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zürich, Switzerland
Further Information

Publication History

Received: August 3, 2002

Accepted: December 15, 2002

Publication Date:
12 June 2003 (online)

Preview

Abstract

Cytotoxicity-guided fractionation of the methanol soluble part of the dichloromethane extract of the leaves of Warionia saharae led to the isolation of the two new guaianolide-type sesquiterpene lactones, 5αH-3β,4β-epoxy-14-oxo-guaia-1(10),11(13)-dien-6α,12-olide (1), 5α H-2β,4β-epoxy-3α-hydroxy-guaia-1(10),11(13)-dien-6α,12-olide (6), and the new eudesmane type sesquiterpene 1β,6α-dihydroxycostic acid (4). In addition, the known sesquiterpene lactones 5α H-2β-hydroxyguaia-3(4),10(14),11(13)-trien-6α,12-olide (2), reynosin (3), 5α H-1α,10α:3α,4α-diepoxyguaia-11(13)-en-6α,12-olide (5), and dehydroleucodin (7) were isolated together with the known flavone hispidulin. Cytotoxicity testing of the sesquiterpene lactones against the KB cancer cell line (ATCC CCL17) revealed IC50 values of 3.5 (1), 2.6 (2), 2.7 (3), 4.3 (5), 3.6 (6), and 1.3 (7) μg/mL. Compound 4 was not active up to 20 μg/mL.

References

PD Dr. Jörg Heilmann

Swiss Federal Institute of Technology (ETH) Zurich

Institute of Pharmaceutical Sciences

Winterthurerstr. 190

8057 Zürich

Switzerland

Phone: +41-1-6356049

Fax: +41-1-6356882

Email: joerg.heilmann@pharma.anbi.ethz.ch