Zusammenfassung
Der Goldstandard für medikamentöse und diätetische Studien bleibt die randomisierte,
plazebokontrollierte Interventionsstudie. Um die Wirksamkeit der antioxidativen Vitamine
auf die Verhütung der Atherogenese und Karzinogenese zu prüfen, wurden in den vergangenen
zehn Jahren neun randomisierte Interventionsstudien an über 110 000 Männern und Frauen
in Europa und den USA durchgeführt. In keiner dieser über mindestens drei und maximal
zwölf Jahre laufenden Studien wurden im Vergleich zu Plazebo positive Ergebnisse erreicht.
Vom Gebrauch von Supplementen mit hohen Dosen von antioxidativen Vitaminen sollte
in Zukunft abgeraten werden, da bereits erste Resultate mit hohen Dosen von Vitaminen
auf gefährliche Komplikationen hinweisen.
Abstract
Between 1992 and 2002, the results of nine randomized, placebo-controlled trials were
reported after testing the effectiveness of antioxidant vitamins to prevent or treat
coronary heart disease and cancer. A total of over 110 000 men and women in the United
States and Europe were involved in these double-blind intervention studies for a minimum
of three and a maximum of twelve years. Antioxidant vitamins in various supplement
dosages were shown ineffective to influence atherogenesis, and, in two studies, the
combination of beta-carotene treatment and smoking appeared to increase the incidence
of lung cancer. Therefore, the use of vitamin supplements is to be discouraged.
Schlüsselwörter
β-Karotin - Vitamin E - Vitamin C - Supplemente - klinische Wirksamkeit
Key words
β-carotene - vitamin E - vitamin C - supplements - clinical outcome
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Prof. Dr. med. Siegfried Heyden
2729 Montgomery Str. Durham, N.C. 27705
6575 San Nazzaro · Schweiz
