Optically Active Lithium-Alkoxide Catalyzed Asymmetric Reduction of Imines with Trimethoxyhydrosilane

Abstract

Optically active lithium alkoxide catalyzed asymmetric reduction of imines with trimethoxhydroysilane in moderate enantioselectivity (up to 72% ee).

Key words

asymmetric reduction - lithium alkoxide - imine - solvent effect

References

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8

We have already found that diastereoselectivity was switched by selection of solvent in the reduction of α,β-epoxyketones. See ref. [4b]