The M235T Variant of the Angiotensinogen Gene and the Body Mass Index Are Useful Markers for Prevention of Hypertension in Pregnancy: A Tree-Based Analysis of Gene-Environment Interaction

Gen Kobashi; Akira Hata; Koichi Shido; Kaori Ohta; Hideto Yamada; Seiichiro Fujimoto; Kiyotaro Kondo

doi:10.1055/s-2002-36690

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2002; 28(6): 501-506
DOI: 10.1055/s-2002-36690

The M235T Variant of the Angiotensinogen Gene and the Body Mass Index Are Useful Markers for Prevention of Hypertension in Pregnancy: A Tree-Based Analysis of Gene-Environment Interaction

Gen Kobashi¹ , Akira Hata² , Koichi Shido¹ , Kaori Ohta¹ , Hideto Yamada³ , Seiichiro Fujimoto³ , Kiyotaro Kondo⁴

¹Division of Preventive Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
²Department of Public Health, Asahikawa Medical College, Asahikawa, Japan
³Division of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
⁴The University of the Air, Chiba, Japan

Abstract

ABSTRACT

We sought to perform a tree-based analysis of lifestyle risk factors for hypertension in pregnancy (HP) with univariate and multivariate analyses. Seventy-eight HP patients and 199 normal controls were recruited from primiparous women 20 to 34 years of age. Data from angiotensinogen (AGT) genotyping and data from a self-administered questionnaire about lifestyle were subjected to univariate and multivariate analyses. By dividing the subjects into two subgroups-those who possessed "the TT genotype of AGT" and "body mass index (BMI) < 24" and those who did not-we were able to examine the acquired risk factors for HP during pregnancy in these two groups. Multivariate analysis selected "mentally stressful condition" and "no antenatal training during pregnancy" in the former group, and "poorly balanced diet" in the latter group. Determination of factors obvious before pregnancy, such as genotype or prepregnancy BMI, may be useful for devising effective individualized strategies for preventing HP.

KEYWORD

Hypertension - pregnancy - genetics - angiotensinogen - tree-based analysis

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