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DOI: 10.1055/s-2002-34109
© Georg Thieme Verlag Stuttgart · New York
Rezeptorliganden für die Bildgebung der Neurotransmission mit SPECT und PET
Radiotracer for Neurotransmission Imaging with SPECT and PETPublication History
Publication Date:
16 September 2002 (online)

Zusammenfassung
Neben Entwicklungen in der Radiopharmazie sind es erhebliche Fortschritte auf dem Gebiet der Kameratechnik und Datenverarbeitung, die den klinischen Einsatz von spezifischen und selektiven Neurotracern nicht nur für PET, sondern auch für SPECT ermöglichen. Während für PET eine Vielzahl von Radioliganden zur Verfügung stehen, sind es nur relativ wenige für SPECT. Daneben werden immer neue Radiopharmaka für die neurologische Diagnostik und Forschung synthetisiert und laufend weiterentwickelt. Aber auch bereits bekannte Tracer werden für spezielle klinische Fragestellungen neu entdeckt und eingesetzt.
Abstract
Besides the developments in radiopharmaceutical chemistry it is the considerable progress in the field of camera technology and data processing, which make the clinical use of high specific and selective radiotracers possible not only for PET but also for SPECT. Although radioligands for application in PET are relatively numerous, those for SPECT are markedly fewer. A variety of new radiotracers have been synthesized for neurological diagnostic and research and were always developed further to improve their biochemical properties. But also well-known tracers are discovered and occurred newly for special clinical questions.
Schlüsselwörter
Rezeptorligand - Dopamin-D2-Rezeptor - Serotoninrezeptor - Benzodiazepin - Wiederaufnahmeinhibitor - Metabolismus
Key words
Tracer - Dopamine D-2 receptor - Serotonin-receptor - Benzodiazepine - Reuptake inhibitor - Metabolism
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Dipl.-Chem. Dr. rer. medic. F. J. Gildehaus
Labor für Radiopharmazeutische Chemie
Klinik und Poliklinik für Nuklearmedizin
Klinikum der Universität München-Großhadern
Marchioninistraße 15
81377 München
Email: gildehaus@nuk.med.uni-muenchen.de