Planta Med 2002; 68(7): 615-620
DOI: 10.1055/s-2002-32910
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Antimicrobial Flavonoids from Bolusanthus speciosus

Gomotsang Bojase1 , Runner R.T. Majinda1 , Berhanu A. Gashe2 , Cornelius C.W. Wanjala3
  • 1Department of Chemistry, University of Botswana, Gaborone, Botswana
  • 2Department of Biological Sciences, University of Botswana, Gaborone, Botswana
  • 3Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya
Further Information

Publication History

Received: September 29, 2001

Accepted: April 7, 2002

Publication Date:
22 July 2002 (online)

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Abstract

A new isoflavanone namely 3,5,7,2′,4′-pentahydroxy-8,3′-di(γ,γ-dimethylallyl)isoflavanone (bolusanthin II) and four new pterocarpans identified as 3-hydroxy-6′,6′-dimethylpyrano[2′,3′:1,2] [6aR,11aR]-8,9-methylenedioxypterocarpan (bolucarpan A), 3-hydroxy-6′,6′-dimethyl-4′,5′-dihydropyrano[2′,3′:1,2][6aR,11aR]- 8,9-methylenedioxypterocarpan (bolucarpan B), 3-hydroxy-9-methoxy-6′,6′-dimethylpyrano-[2′,3′:1,2][6aR,11aR]-pterocarpan (bolucarpan C) and 3-hydroxy-9-methoxy-6′,6′-dimethyl-4′,5′-dihydropyrano[2′,3′:1,2][6aR,11aR]-pterocarpan (bolucarpan D) and three known isoflavonoids were isolated from the methanolic extracts of the root bark, while eight known isoflavonoids were isolated from the stem bark of Bolusanthus speciosus. These compounds showed antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Saccharomyces cerevisiae and Candida mycoderma using the agar overlay technique.

References

Dr. R. R.T. Majinda

Department of Chemistry

University of Botswana

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Botswana

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