Abstract
The antiviral and antioxidant activity of some fractions and of a series of flavonoids
and proanthocyanidins obtained from Crataegus sinaica (Rosaceae) was evaluated. The O-glycosidic flavonoids and the oligomeric proanthocyanidins exhibited significant
inhibitory activity against herpes simplex virus type 1 (HSV-1), which was shown to
be due to an extracellular mechanism for procyanidin C-1. Procyanidin C-1 also had
the highest antioxidant activity in both the microsomal lipid peroxidation and the
hydroxyl radical scavenging assay. In addition to the previously reported phenolic
compounds, the pentacyclic triterpenoid ursolic acid (1) and a tetrameric (2) and pentameric procyanidin (3) are reported for the first time.
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Prof. Dr. L. Pieters
Department of Pharmaceutical Sciences
University of Antwerp
Universiteitsplein 1
2610 Antwerp, Belgium
Email: pieters@uia.ua.ac.be
Fax: (+32) 3 820 27 09