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Planta Med 2001; 67(8): 776-778
DOI: 10.1055/s-2001-18352
Letter

© Georg Thieme Verlag Stuttgart · New York

A New Lignan Glycoside from Eleutherococcus senticosus

Xing-Cong Li1 , Dayna L. Barnes1 , Ikhlas A. Khan1, 2,*
  • 1 National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi, USA
  • 2 Department of Pharmacognosy, School of Pharmacy, University of Mississippi, Mississippi, USA
Further Information

Publication History

October 10, 2000

February 15, 2001

Publication Date:
09 November 2001 (online)

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Abstract

A new lignan glycoside, named eleutheroside E2 (1), has been isolated from the roots of Eleutherococcus senticosus (known as “Siberian ginseng”), along with isomaltol 3-O-α-D-glucopyranoside (2), eleutherosides B, E and E1, and thymidine. The structure of 1 was established by spectral interpretations as episyringaresinol 4″-O-β-D-glucopyranoside. Compound 2 is described here for the first time as a naturally occurring compound.

References

  • 1 Farnsworth N R, Kinghorn A D, Soejarto D D, Waller D P. Siberian ginseng (Eleutherococcus senticosus): current status as an adaptogen. In: Wagner H, Hikino H, Farnsworth NR, editors Economic and medicinal plant research. Vol. 1 New York; Academic Press 1985: 156-209
    Google Scholar
  • 2 Yat P N, Arnason J T, Awang D VC. An improved extraction procedure for the rapid, quantitative high-performance liquid chromatography estimation of the main eleutherosides (B and E) in Eleutherococcus senticosus (Eleuthero).  Phytochemical Analysis. 1998;  9 291-5
    CrossrefPubMedGoogle Scholar
  • 3 Goodwin J. Isolation of 3-O-α-D-gluco- and 3-O-β-D-galacto-pyranosyloxy-2-furyl methyl ketones from nonenzymic browing of maltose and lactose with secondary amino acids.  Carbohydrate Research. 1983;  115 281-7
    CrossrefPubMedGoogle Scholar
  • 4 Niwa M, Iwadare Y, Wu Y C, Hirata Y. Two new phenylpropanoid glycosides from Wikstroemia sikokiana .  Chem. Pharm. Bull.. 1988;  36 1158-61
    PubMedGoogle Scholar
  • 5 Lami N, Kadota S, Kikuchi T, Momose Y. Constituents of the roots of Boerhaavia diffusa L. III. Identification of Ca++ channel antagonistic compound from the methanol extract.  Chem. Pharm. Bull.. 1991;  39 1551-5
    CrossrefPubMedGoogle Scholar
  • 6 Chen Z, Lu Y, Xu P, Gao Y, Deng K, Chen C. Studies on the water soluble constituents of Chinese drugs beimu, the bulbs of Fritillaria plants.  Zhongguo Zhongyao Zazhi. 1996;  21 420-2
    PubMedGoogle Scholar
  • 7 Briggs L H, Cambie R C, Couch R AF. Lirioresinol-C dimethyl ether, a diaxially substituted 3,7-dioxybicyclo[3,3,0]octane lignan from Macropiper excelsum (Forst.f.) Mig. J. Chem. Soc. (C) 1968: 3042
    Google Scholar
  • 8 Pelter A, Ward R S, Rao E V, Sastry K V. Revised structures for pluviatilol, methyl pluviatilol and xanthoxylol.  Tetrahedron. 1976;  32 2783-8
    CrossrefPubMedGoogle Scholar
  • 9 Dickey E E. Liriodendrin, a new lignan diglucoside from the inner bark of yellow poplar (Liriodendron tulipifera L.)  J. Org. Chem.. 1958;  23 179-84
    CrossrefPubMedGoogle Scholar
  • 10 Wang C, Jia Z. Lignan, phenylpropanoid and iridoid glycosides from Pedicularis torta .  Phytochemistry. 1997;  45 159-66
    CrossrefPubMedGoogle Scholar

Dr. Ikhlas A Khan

National Center for Natural Products Research

Research Institute of Pharmaceutical Sciences

School of Pharmacy

University of Mississippi

Mississippi 38677

USA

Email: rikhan@olemiss.edu

Phone: Tel.: +1-662-915-7821

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