Multivariate Analysis of Genetic and Acquired Factors; T235 Variant of the Angiotensinogen Gene Is a Potent Independent Risk Factor for Preeclampsia

Gen Kobashi; Koichi Shido; Akira Hata; Hideto Yamada; Emi-Hirayama Kato; Masao Kanamori; Seiichiro Fujimoto; Kiyotaro Kondo

doi:10.1055/s-2001-14073

Seminars in Thrombosis and Hemostasis, Inhaltsverzeichnis

Semin Thromb Hemost 2001; 27(2): 143-148
DOI: 10.1055/s-2001-14073

Multivariate Analysis of Genetic and Acquired Factors; T235 Variant of the Angiotensinogen Gene Is a Potent Independent Risk Factor for Preeclampsia

Gen Kobashi¹ , Koichi Shido¹ , Akira Hata¹ , Hideto Yamada² , Emi-Hirayama Kato² , Masao Kanamori³ , Seiichiro Fujimoto² , Kiyotaro Kondo⁴

¹Department of Preventive Medicine, Hokkaido University Graduate School of Medicine, Sappor, Japan
²Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
³Department of Public Health, Hamamatsu University School of Medicine, Hamamatsu, Japan
⁴The University of the Air, Chiba, Japan

Abstract

ABSTRACT

Preeclampsia is known to be a multifactorial disease. Recently, the angiotensinogen gene has been shown to be a candidate gene that could be related to preeclampsia, and acquired factors such as lifestyle during pregnancy have also been considered to be risk factors. The aim of this study was to investigate the interrelations among the angiotensinogen gene and various acquired risk factors in preeclampsia. Fifty-eight primiparous patients with preeclampsia were compared with 164 normal primiparous controls. A variant of the angiotensinogen gene (M235T) was analyzed along with the acquired factors obtained from both medical records and a questionnaire consisting of 98 questions. Univariate analysis disclosed 11 factors that were significantly associated with preeclampsia (P < .05). Multivariate analysis revealed four significant independent factors: ``prepregnancy high body mass (body mass index ≥ 24),'' ``T235 homozygotes of the angiotensinogen gene,'' ``mentally stressful condition during pregnancy,'' and ``salty dishes preferred during pregnancy.'' The odds ratios of the four factors were 6.2, 2.5, 3.0 and 2.6, respectively, in a multiple logistic model. Our results support the concept that T235 of the angiotensinogen gene is a potent, independent risk factor for preeclampsia, as well as other lifestyle-related risk factors.

KEYWORD

Preeclampsia - multivariate analysis - lifestyle - angiotensinogen - polymorphism

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Referenzen

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