ABSTRACT
The role of human chorionic gonadatropin (hCG) in the maintenance of early pregnancy
is well known. Recent data suggests that hCG may play a role in the maintenance of
the later stages of pregnancy as well, by directly and indirectly promoting uterine
quiescence. If hCG acts as an endogenous tocolytic in normal pregnancy, then it may
be an ideal candidate for therapy of preterm labor as well. We present compelling
in vitro as well as in vivo data, which support the role of hCG in the maintenance
of normal uterine quiescence. Additionally, we will present in vivo and in vitro data
that confirms the ability of hCG to directly promote relaxation of uterine contractions.
This review provides a basis for future study of the use of hCG in clinical obstetrics.
Given the limited effectiveness of tocolytic therapies available at the time, hCG
may provide a promising pharmacological approach to the pervasive problem of preterm
labor in human pregnancy. While further work is needed, initial data strongly support
this novel use of hCG in clinical obstetrics.
KEYWORD
hCG - pregnancy - uterine quiescence - preterm labor - tocolytic therapy
