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Semin Reprod Med 2001; 19(1): 049-054
DOI: 10.1055/s-2001-13910
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Effects of Human Chorionic Gonadotropin on Trophoblast Invasion

D. Islami, P. Mock, P. Bischof
  • Department of Obstetrics and Gynaecology, University of Geneva, Geneva, Switzerland
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Publication History

Publication Date:
31 December 2001 (online)

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ABSTRACT

Recent studies have shown that different populations of trophoblastic cells of first-trimester human placenta express human chorionic gonadotropin/luteinizing hormone (hCG/LH) receptors. Among these trophoblastic cells, extravillous cytotrophoblasts (CTBs) not only express hCG/LH receptors but also present an invasive phenotype. CTB invasion is instrumental in blastocyst implantation and later in placentation and is tightly regulated in both time and space. This article describes some of the regulators of CTB invasion and summarizes and discusses the potential autocrine/paracrine role of hCG in trophoblast invasion.

KEYWORD

hCG - trophoblast invasion - metalloproteinases - integrins

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