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Minim Invasive Neurosurg 2001; 44(1): 50-57
DOI: 10.1055/s-2001-13583
ORIGINAL PAPER
Georg Thieme Verlag Stuttgart · New York

Effects of Electrical Stimulation of the Gasserian Ganglion on Regional Cerebral Blood Flow after Induced Subarachnoid Hemorrhage in Pigs Evaluated by 99mTc-HMPAO-SPECT

H. Ebel1 , G. Semmelmann1 , M. Friese6 , M. Volz1 , J. Y. Lee1 , M. Dück2,, K. Schomäcker3 , J. Varga4 , I. Furka5 , R. Schröder6 , N. Klug1
  • 1Department of Neurosurgery, University of Cologne, Germany
  • 2Department of Anesthesiology and Intensive Care, University of Cologne, Germany
  • 3Department of Nuclear Medicine, University of Cologne, Germany
  • 4Department of Nuclear Medicine, University of Debrecen, Hungary
  • 5Department of Experimental Surgery, University of Debrecen, Hungary
  • 6Department of Pathology, University of Cologne, Germany
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Publikationsverlauf

Publikationsdatum:
31. Dezember 2001 (online)

    Lizenzen und Reprints

It could be demonstrated that cervical spinal cord stimulation increases cerebral blood flow. The effects of electrical stimulation of the trigeminal ganglion in the acute phase of SAH in pigs were investigated. The experiments were carried out on 11 domestic pigs divided in two groups (group I: SAH [n = 5]; group II: SAH and trigeminal stimulation [n = 6]). In all animals a native SPECT was performed. The Gasserian ganglion was exposed for inserting the stimulation electrode. SAH was induced by injecting 10 ml autologous blood through a catheter placed in the suprasellar cistern. 30 minutes after SAH-induction electrical stimulation was started for two hours in group II (2.8 - 4.5 V, 50 Hz, 300 μs). 99mTc-HMPAO (400 - 540 MBq) was injected intravenousely 110 minutes later. In group I 99mTc-HMPAO was applied after the same time interval. 80 minutes later SPECT was performed. Data were processed to calculate the uptake of radioactivity (%/kg tissue weight). The mean values were calculated for the different groups: native animal examination (%/kg tissue weight): 0.6343; group I: 0.468; group II: 0.6533. Comparing the mean values a highly significant difference between group I and group II (p < 0.01) and between native examination and group I (p < 0.01) could be found. No statistical significance could be detected on comparing the left/right-ratio in any ROI. The electrical stimulation of the Gasserian ganglion leads to a significantly increased uptake of 99mTc-HMPAO after induced SAH. Maybe the stimulation of the Gasserian ganglion constitutes a new therapeutic modality treating disturbed rCBF after SAH.

Key words:

rCBF - SAH - SPECT - Trigeminal stimulation

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Corresponding Author

Dr. med H Ebel

Department of Neurosurgery
University of Cologne

Joseph-Stelzmann-Str. 9
50924 Cologne
Germany

Telefon: Phone:+49-221-4784557

Fax: Fax:+49-221-4785921

eMail: E-mail:Gregor.Semmelmann@t-online.de

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