Planta Med 2001; 67(3): 282-284
DOI: 10.1055/s-2001-12013
Letter

© Georg Thieme Verlag Stuttgart · New York

Vasorelaxing Effect of Coumarins from Cnidium monnieri on Rabbit Corpus Cavernosum

Wen-Fei Chiou, Yu-Lin Huang, Chieh-Fu Chen, Chien-Chih Chen3
  • National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China
Further Information

Publication History

April 26, 2000

November 11, 2000

Publication Date:
31 December 2001 (online)

Abstract

Bioassay-directed fractionation led to the identification of four known coumarins, osthole (1), imperatorin (2), xanthotoxin (3), and isopimpinellin (4), from the ethanolic extract of the fruit of Cnidium monnieri (L.) Cusson. In phenylephrine (PE)-precontracted endothelium-intact rabbit corpus cavernosum, all four coumarins exhibited relaxing effect with the IC50 values for compounds 1, 2, 3, and 4 determined to be 2.14 ± 0.73, 0.85 ± 0.16, 1.24 ± 0.45, and 18.4 ± 8.10 μM, respectively. The four compounds were identified by comparision of their physical data (EIMS, 1H- and 13C-NMR) with those from published reports.

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Prof. Chien-Chih Chen

National Research Institute of Chinese Medicine

No. 155 - 1, Sec. 2

Li Nung St.

Peitou

Taipei 11221

Taiwan

Republic of China

Email: ccchen@cma23,nricm.edu.tw

Fax: +886-2-28264276

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