Abstract
Piperine (1), an alkaloid of black and long peppers, inhibited gastric emptying (GE) of solids/liquids
in rats and gastrointestinal transit (GT) in mice in a dose and time dependent manner.
Compound 1 significantly inhibited GE of solids and GT at the doses extrapolated from humans
(1 mg/kg and 1.3 mg/kg p.o. in rats and mice, respectively). However, at the same dose the effect was insignificant
for GE of liquids. One week oral treatment of 1 mg/kg and 1.3 mg/kg in rats and mice,
respectively, did not produce a significant change in activity as compared to single
dose administration. GE inhibitory activity of 1 is independent of gastric acid and pepsin secretion.
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Dr. K. L. Bedi
Chairman
Pharmacology Division
Regional Research Laboratory
Canal Road
Jammu 180 001
India
eMail: rrlj@nde.vsnl.net.in or sbajad@yahoo.com