Planta Med 2000; 66(3): 257-261
DOI: 10.1055/s-2000-8570
Original Paper
Georg Thieme Verlag Stuttgart · New York

New Phenylethanoids from Buddleja cordata subsp. cordata

Laura Acevedo1 , Emma Martínez1 , Perla Castañeda1 , Scott Franzblau2 , Barbara N. Timmermann3 , Edelmira Linares4 , Robert Bye4 , Rachel Mata1,*
  • 1 Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, D.F., México
  • 2 G. W. L. Hansen's Disease Center, Baton Rouge, Louisiana, U.S.A.
  • 3 Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizone, Tucson, Arizona, U.S.A.
  • 4 Instituto de Biología, Universidad Nacional Autónoma de México, D.F., México
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Abstract

Bioassay-guided fractionation of a crude extract of the stem bark of Buddleja cordata subsp. cordata with significant antimycobacterial activity led to the isolation of a mixture composed by ten new long-chain esters of 2[4′-hydroxyphenyl]-ethanol (1 - 10), along with the lichen metabolites methyl β-orcinolcarboxylate (11) and β-orcinolcarboxylate (12). Extensive HPLC allowed the separation of the major components of the mixture, which were characterized by spectral means as 2[4′-hydroxyphenyl]-ethyl stearate (3), 2[4′-hydroxyphenyl]-ethyl behenate (6), and 2[4′-hydroxyphenyl]-ethyl lignocerate (8). The minor esters were identified as 2[4′-hydroxyphenyl]-ethyl palmitate (1), 2[4′-hydroxyphenyl]-ethyl heptadecanoate (2), 2[4′-hydroxyphenyl]-ethyl nonadecanoate (4), 2[4′-hydroxyphenyl]-ethyl arachidate (5), 2[4′-hydroxyphenyl]-ethyl tricosanoate (7), 2[4′-hydroxyphenyl]-ethyl pentacosanoate (9), and 2[4′-hydroxyphenyl]-ethyl hexacosanoate (10) by GC-MS analysis of the methyl esters derivatives of the fatty acids obtained by alkaline hydrolysis of the mixture. Compound 8 exhibited moderate antibacterial activity against Mycobacterium tuberculosis (MIC = 64 μg/ml).

References

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Dr. Rachel Mata

Facultad de Química Universidad Nacional Autónoma de México

Coyoacán 04510

México D.F.

México

Email: rachel@servidor.unam.mx.