Oral-medikamentöse Therapie der erektilen Dysfunktion: Grundlagen, Spektrum und Grenzen

Zusammenfassung

Das Behandlungsspektrum der erektilen Dysfunktion (ED) spannt sich von der oral-medikamentösen Therapie bis zur Implantation einer Penisprothese. Die bedarfsangepaßte („on demand”) Tabletteneinnahme wird von der Mehrzahl der Patienten mit ED bevorzugt. In der Kategorie der zentralen Initiatoren der Erektion ist die wichtigste Substanz Apomorphin SL, dessen klinische Prüfungen abgeschlossen sind. In der Kategorie der peripheren Konditioner der Erektion stehen die klinischen Prüfungen der Phentolamidinmesylat oral vor dem Abschluß. Die innovativste Substanz dieser Kategorie ist Sildenafil, der erste Phosphodiesterase-5-Hemmer, der in Deutschland zugelassen ist.

Abstract

The therapeutic spectrum of erectile dysfunction comprises the oral-medical therapy at one end and the implantation of a penile prothesis at the other end. The majority of patients with erectile dysfunction favours the intake of tablets „on demand”. In the category of central initiators of erection, apomorphine SL is the most important compound, the clinical trials are now completed. In the category of peripheral conditioners of erection, the clinical trials with phentolaminmesylate per os are about to be concluded. The true novel substance in this category is sildenalfil, the first phosphodiesterase-5-inhibitor which has been approved in Germany.

Key words:

Erectile dysfunction - Oral treatment.

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