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Digestive Disease Interventions
DOI: 10.1055/s-0045-1807743
Review Article

Endoscopic Evaluation and Therapy of Intraductal Papillary Mucinous Neoplasms

Nikhil Bush
1   Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama
,
Shreyas Krishna
2   Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio
,
Ahmed Abdelbaki
2   Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio
,
Eileen S. Carpenter
3   Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan
,
Jorge D. Machicado 
3   Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan
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Abstract

As the understanding of intraductal papillary mucinous neoplasms (IPMNs) continues to evolve, so too do the diagnostic and therapeutic strategies surrounding its management. This review article aims to provide a comprehensive overview of the endoscopic evaluation and therapeutic interventions available for patients with IPMNs. Endoscopic ultrasound (EUS) plays a pivotal role in the diagnosis and risk stratification of IPMNs. Furthermore, advancements in EUS techniques, such as needle-based confocal laser endomicroscopy, contrast-enhanced EUS, and through-the-needle biopsies, provide additional diagnostic precision in the evaluation of IPMNs. The role of therapeutic interventions for IPMNs has emerged over the past decade and includes chemoablation and radiofrequency ablation, which offer minimally invasive alternatives to surgery in select cases. With this progress in endoscopic techniques, endoscopists are better equipped than ever to diagnose, risk-stratify, and treat patients with IPMNs.

Keywords

IPMN - pancreatic cyst - pancreatic cancer - endomicroscopy - chemoablation

Disclosures and Conflicts of Interest

J.D.M. is funded by an ACG Junior Faculty Career Development Award and Robert A. Winn Excellence in Clinical Trials Career Development Award. He has also served on the advisory board of Amgen LCM and as a speaker for Maunea Kea Technologies, Paris, France.




Publication History

Received: 10 August 2024

Accepted: 21 March 2025

Article published online:
15 April 2025

© 2025. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
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